Does helping mothers in multigenerational ADHD also help children in the long run? 2-year follow-up from baseline of the AIMAC randomized controlled multicentre trial

Julia M Geissler^#¹, Timo D Vloet^#², Nora Strom², Charlotte Jaite³, Erika Graf⁴, Viola Kappel³, Andreas Warnke², Christian Jacob⁵, Klaus Hennighausen⁶, Barbara Haack-Dees⁶, Katja Schneider-Momm⁶, Swantje Matthies⁷, Michael Rösler⁸, Wolfgang Retz^{8

9}, Susann Hänig¹⁰, Alexander von Gontard¹⁰, Esther Sobanski^{11

12}, Barbara Alm¹¹, Sarah Hohmann¹³, Luise Poustka¹⁴, Michael Colla¹⁵, Laura Gentschow³, Christine M Freitag¹⁶, Alexander Häge¹³, Martin Holtmann¹⁷, Katja Becker^{13

18}, Alexandra Philipsen^{7

19}, Thomas Jans²

Affiliations

¹ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany. Geissler_J@ukw.de.
² Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
³ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁴ Institute of Medical Biometry and Statistics, Clinical Trials Unit, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
⁵ Clinic for Psychiatry and Psychotherapy, Medius Clinic, Kirchheim, Germany.
⁶ Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
⁷ Department of Psychiatry and Psychotherapy, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
⁸ Institute for Forensic Psychology and Psychiatry, Faculty of Medicine, Saarland University, Homburg, Germany.
⁹ Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.
¹⁰ Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of Medicine, Saarland University Hospital, Homburg, Germany.
¹¹ Clinic for Psychiatry and Psychotherapy, Central Institute for Mental Health Mannheim, Mannheim, Germany.
¹² Department of Child and Adolescent Psychiatry and Psychotherapy Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.
¹³ Clinic for Child and Adolescent Psychiatry and Psychotherapy, Central Institute for Mental Health Mannheim, Mannheim, Germany.
¹⁴ Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
¹⁵ Department of Psychiatry and Psychotherapy, Universitätsmedizin Rostock, Rostock, Germany.
¹⁶ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
¹⁷ Hospital for Child and Adolescent Psychiatry, LWL University Hospital Hamm of the Ruhr University Bochum, Bochum, Germany.
¹⁸ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Marburg, Germany.
¹⁹ Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.

^# Contributed equally.

PMID: 31807943
DOI: 10.1007/s00787-019-01451-0

Does helping mothers in multigenerational ADHD also help children in the long run? 2-year follow-up from baseline of the AIMAC randomized controlled multicentre trial

Julia M Geissler et al. Eur Child Adolesc Psychiatry. 2020 Oct.

. 2020 Oct;29(10):1425-1439.

doi: 10.1007/s00787-019-01451-0. Epub 2019 Dec 5.

Authors

Affiliations

¹ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany. Geissler_J@ukw.de.
² Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany.
³ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁴ Institute of Medical Biometry and Statistics, Clinical Trials Unit, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
⁵ Clinic for Psychiatry and Psychotherapy, Medius Clinic, Kirchheim, Germany.
⁶ Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
⁷ Department of Psychiatry and Psychotherapy, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
⁸ Institute for Forensic Psychology and Psychiatry, Faculty of Medicine, Saarland University, Homburg, Germany.
⁹ Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.
¹⁰ Department of Child and Adolescent Psychiatry and Psychotherapy, Faculty of Medicine, Saarland University Hospital, Homburg, Germany.
¹¹ Clinic for Psychiatry and Psychotherapy, Central Institute for Mental Health Mannheim, Mannheim, Germany.
¹² Department of Child and Adolescent Psychiatry and Psychotherapy Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.
¹³ Clinic for Child and Adolescent Psychiatry and Psychotherapy, Central Institute for Mental Health Mannheim, Mannheim, Germany.
¹⁴ Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
¹⁵ Department of Psychiatry and Psychotherapy, Universitätsmedizin Rostock, Rostock, Germany.
¹⁶ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
¹⁷ Hospital for Child and Adolescent Psychiatry, LWL University Hospital Hamm of the Ruhr University Bochum, Bochum, Germany.
¹⁸ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Philipps-University of Marburg, Marburg, Germany.
¹⁹ Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.

^# Contributed equally.

PMID: 31807943
DOI: 10.1007/s00787-019-01451-0

Erratum in

Correction to: Does helping mothers in multigenerational ADHD also help children in the long run? 2‑year follow‑up from baseline of the AIMAC randomized controlled multicentre trial.
Geissler JM, Vloet TD, Strom N, Jaite C, Graf E, Kappel V, Warnke A, Jacob C, Hennighausen K, Haack-Dees B, Schneider-Momm K, Matthies S, Rösler M, Retz W, Hänig S, von Gontard A, Sobanski E, Alm B, Hohmann S, Poustka L, Colla M, Gentschow L, Freitag CM, Häge A, Holtmann M, Becker K, Philipsen A, Jans T. Geissler JM, et al. Eur Child Adolesc Psychiatry. 2021 Jan;30(1):177. doi: 10.1007/s00787-019-01465-8. Eur Child Adolesc Psychiatry. 2021. PMID: 31897848 No abstract available.

Abstract

ADHD often affects multiple generations in a family. Previous studies suggested that children with ADHD benefit less from therapy if parents are also affected, since ADHD symptoms interfere with treatment implementation. This two-group randomised controlled trial examined whether targeting maternal ADHD boosts the efficacy of parent-child training (PCT) for the child's ADHD. Here, we report follow-up results 2 years from baseline. Mothers of 144 mother-child dyads (ADHD according to DSM-IV) were examined for eligibility (T1) and randomised to 12 weeks of intensive multimodal treatment comprising pharmacotherapy and DBT-based cognitive behavioural group psychotherapy (TG, n = 77) or clinical management comprising non-specific counselling (CG, n = 67) for Step 1 (concluded by T2). Subsequently, all dyads participated in 12 weekly PCT sessions for Step 2 (concluded by T3). In Step 3, participants received maintenance treatments for 6 months (concluded by T4). At 24 months after baseline (T5), we performed follow-up assessments. The primary endpoint was child ADHD/ODD score (observer blind rating). Outcomes at T5 were evaluated using ANCOVA. Assessments from 101 children and 95 mothers were available at T5. Adjusted means (m) of ADHD/ODD symptoms (range 0-26) in children did not differ between TG and CG (mean difference = 1.0; 95% CI 1.2-3.1). The maternal advantage of TG over CG on the CAARS-O:L ADHD index (range 0-36) disappeared at T5 (mean difference = 0.2; 95% CI - 2.3 to 2.6). Sensitivity analyses controlling for medication and significant predictors of follow-up participation showed unchanged outcomes. Within-group outcomes remained improved from baseline. At the 24-month follow-up, TG and CG converged. The superiority of intensive treatment regarding maternal symptoms disappeared. In general, cross-generational treatment seems to be effective in the long term. (BMBF grant 01GV0605; registration ISRCTN73911400).

Keywords: Cross-generational ADHD treatment; Follow-up; Maternal ADHD; Methylphenidate; Multiplex families; Parent child training.

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Does helping mothers in multigenerational ADHD also help children in the long run? 2-year follow-up from baseline of the AIMAC randomized controlled multicentre trial

Affiliations

Does helping mothers in multigenerational ADHD also help children in the long run? 2-year follow-up from baseline of the AIMAC randomized controlled multicentre trial

Authors

Affiliations

Erratum in

Abstract

References

Grants and funding

LinkOut - more resources

Full Text Sources

Miscellaneous