Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988;48(1):48-50.
doi: 10.1159/000132584.

Localization of the human dopamine beta hydroxylase (DBH) gene to chromosome 9q34

S P Craig  1 , V J Buckle, A Lamouroux, J Mallet, I W Craig
Affiliations

Localization of the human dopamine beta hydroxylase (DBH) gene to chromosome 9q34

S P Craig et al. Cytogenet Cell Genet. 1988.

Abstract

A human cDNA clone for dopamine beta hydroxylase (DBH) has been isolated from a phaeochromocytoma library. In situ hybridization of this probe to replication-banded chromosomes has localized the gene to chromosome 9q34. The structural gene for the enzyme is therefore close to the ABO blood group locus. This suggests that the previously described activity variation in levels of serum DBH may reflect alterations in either the structure or regulation of the DBH coding sequences. Both biochemical and genetic evidence therefore indicate independence of DBH from the pterin-dependent aromatic amino acid hydroxylases of the neurotransmitter pathways.

PubMed Disclaimer

LinkOut - more resources