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Meta-Analysis
. 2019 Dec 20;39(12):BSR20190744.
doi: 10.1042/BSR20190744.

A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus

Bo Huang  1 , Yu-Kun Wang  2 , Lin-Yuan Qin  1 , Qin Wei  1 , Nian Liu  1 , Min Jiang  1 , Hong-Ping Yu  3 , Xiang-Yuan Yu  1
Affiliations
Meta-Analysis

A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus

Bo Huang et al. Biosci Rep. .

Erratum in

Abstract

The melatonin receptor 1B (MTNR1B) polymorphism rs10830963 C>G has been reported to be associated with the risk of gestational diabetes mellitus (GDM) with inconsistent results. To clarify the effect of the polymorphism on the risk of GDM, a meta-analysis therefore was performed. Pooled OR with its corresponding 95%CI was used to estimate the strength of the association. Totally 14 eligible studies with a number of 5033 GDM patients and 5614 controls were included in this meta-analysis. Results indicated that the variant G allele was significantly associated with an increased GDM risk (CG vs. CC: OR = 1.25, 95% CI = 1.11-1.40, P < 0.001; GG vs. CC: OR = 1.78, 95% CI = 1.45-2.19, P < 0.001; G vs. C: OR = 1.33, 95% CI = 1.21-1.47, P < 0.001). In the stratified analysis by ethnicity, similar results were found in Asians (CG vs. CC: OR = 1.15, 95%CI = 1.02-1.28, P = 0.020; GG vs. CC: OR = 1.52, 95% CI = 1.23-1.89, P < 0.001; G vs. C: OR = 1.23, 95% CI = 1.10-1.37, P < 0.001) and in Caucasians (CG vs. CC: OR = 1.40, 95% CI = 1.16-1.70, P < 0.001; GG vs. CC: OR = 2.21, 95% CI = 1.54-3.17, P < 0.001; G vs. C: OR = 1.47, 95% CI = 1.24-1.73, P < 0.001). FPRP and TSA analyses confirmed findings support that the rs10830963 G allele increases the risk of GDM, and further functional experimental studies are warranted to explore and clarify the potential mechanism.

Keywords: Gestational diabetes mellitus; MTNR1B; Polymorphism; Trial sequential analysis; meta analysis.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. Flowchart of the process of identification of eligible studies
Figure 2
Figure 2. Forest plot on the risk of GDM associated with rs10830963 (CG vs. CC)
Figure 3
Figure 3. Forest plot on the risk of GDM associated with rs10830963 (GG vs. CC)
Figure 4
Figure 4. Forest plot on the risk of GDM associated with rs10830963 (G vs. C)
Figure 5
Figure 5. Sensitivity analyses of the association between rs10830963 C>G and GDM risk under the CG vs. CC comparison
Figure 6
Figure 6. Sensitivity analyses of the association between rs10830963 C>G and GDM risk under the GG vs. CC comparison
Figure 7
Figure 7. Begg’s funnel plot for publication bias test (CG vs. CC)
Figure 8
Figure 8. Begg’s funnel plot for publication bias test (GG vs. CC)
Figure 9
Figure 9. TSA for rs10830963 under the heterozygote model among Asians (CG vs. CC)
Figure 10
Figure 10. TSA for rs10830963 under the heterozygote model among Caucasians (CG vs. CC)
Figure 11
Figure 11. TSA for rs10830963 under the homozygote model among Caucasians (GG vs.CC)
Figure 12
Figure 12. TSA for rs10830963 under the homozygote model among Caucasians (GG vs. CC)
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