Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb;44(2):e13107.
doi: 10.1111/jfbc.13107. Epub 2019 Dec 6.

Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan

Sakina Yagi  1 , Atif B A Mohammed  1 , Tzvetomira Tzanova  2 , Hervé Schohn  3 , Haider Abdelgadir  4 , Azzurra Stefanucci  5 , Adriano Mollica  5 , Gökhan Zengin  6
Affiliations

Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan

Sakina Yagi et al. J Food Biochem. 2020 Feb.

Abstract

Essential oils from the inflorescence of Cymbopogon schoenanthus and C. nervatus growing in Northern Sudan were examined for their chemical composition, antiproliferative activity against human breast carcinoma and human colon adenocarcinoma cell lines, antioxidant activity (phosphomolybdenum, antiradical, reducing power, and ferrous chelating), and enzyme inhibition activity against acetylcholinesterase butyrylcholinesterase, tyrosinase, α-glucosidase, and α-amylase. In silico study on the inhibition of tyrosinase and α-amylase was also performed. Piperitone (59.1%) and isomers of para-menthadienols (35.3%) were the main compounds in C. schoenanthus and C. nervatus oils, respectively. Oil from C. nervatus possessed higher antioxidant activity than that from C. schoenanthus except for its metal chelating ability. Both oils showed high antiproliferative activity. In silico study showed that trans-p-mentha-2,8-dien-1-ol and piperitone (both isomers) revealed the best docking scores for α-amylase and tyrosinase, respectively. In conclusion, oils from these two Cymbopogon species could be new natural agents with functional properties for food, cosmetics, and pharmaceutical industries. PRACTICAL APPLICATIONS: Recently, there is a growing tendency to replace synthetic oils by natural ones in the cosmetic, food, and pharmaceutical products. In this context, we investigated the chemical characterization and biological activities of two Cymbopogon species essential oils (C. schoenanthus (L.) Spreng. and C. nervatus). Antioxidant capacity, enzyme inhibition, and antiproliferative effects were tested for biological activities. Chemical characterization was identified by GC-MS. Based on our findings, the Cymbopogon species may be utilized as sources of natural bioactive agents in food industries.

Keywords: Cymbopogon; antioxidant; antiproliferative; chemical profile; enzyme inhibition.

PubMed Disclaimer

References

REFERENCES

    1. Adefegha, S. A., Olasehinde, T. A., & Oboh, G. (2017). Essential oil composition, antioxidant, antidiabetic and antihypertensive properties of two Afromomum species. Journal of Oleo Science, 66(1), 51-63.
    1. Allied. (2016). Essential oil market by product and application-Global opportunity analysis and industry forecast, 2015-2022. Retrieved from https://www.alliedmarketresearch.com/essential-oils-market
    1. Azhar Ul, H., Malik, A., Khan, M. T., Anwar Ul, H., Khan, S. B., Ahmad, A., & Choudhary, M. I. (2006). Tyrosinase inhibitory lignans from the methanol extract of the roots of Vitex negundo Linn. and their structure-activity relationship. Phytomedicine, 13(4), 255-260. https://doi.org/10.1016/j.phymed.2004.09.001
    1. Bayala, B., Bassole, I. H., Scifo, R., Gnoula, C., Morel, L., Lobaccaro, J.-M.- A., & Simpore, J. (2014). Anticancer activity of essential oils and their chemical components-A review. American Journal of Cancer Research, 4(6), 591.
    1. Berman, H. M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T., Weissig, H., … Bourne, P. (2000). The protein data bank. Nucleic Acids Research, 28, 235-242. https://doi.org/10.1093/nar/28.1.235

LinkOut - more resources