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Comment
. 2019 Dec 5;25(6):729-731.
doi: 10.1016/j.stem.2019.11.008.

Sensing the Environment: Extracellular Lactate Levels Control Adult Neurogenesis

Valentina Scandella  1 , Marlen Knobloch  2
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Sensing the Environment: Extracellular Lactate Levels Control Adult Neurogenesis

Valentina Scandella et al. Cell Stem Cell. .
Free article

Abstract

Metabolism has emerged as a key player for stem cell behavior; however, the role of metabolism in the microenvironment remains poorly understood. In this issue of Cell Stem Cell, Wang et al. (2019) show that brain endothelial cells directly affect adult neural stem cells and maintain a healthy metabolic environment by regulating lactate levels.

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