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Comment
. 2019 Dec 5;76(5):694-696.
doi: 10.1016/j.molcel.2019.11.015.

Birth of Nucleolar Compartments: Phase Separation-Driven Ribosomal RNA Sorting and Processing

Denis L J Lafontaine  1
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Birth of Nucleolar Compartments: Phase Separation-Driven Ribosomal RNA Sorting and Processing

Denis L J Lafontaine. Mol Cell. .
Free article

Abstract

The nucleolus is a phase-separated cell condensate where the initial steps of ribosome biogenesis take place. In this issue of Molecular Cell, Yao et al. (2019) report a super-resolution microscopy analysis of the internal structure of the nucleolus, revealing how nascent precursor ribosomal RNAs are initially partitioned and processed in this multilayered biocondensate.

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