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Review
. 2020 Jan;80(1):1-7.
doi: 10.1016/j.jinf.2019.11.021. Epub 2019 Dec 3.

Rapid syndromic molecular testing in pneumonia: The current landscape and future potential

Stephen Poole  1 , Tristan W Clark  2
Affiliations
Review

Rapid syndromic molecular testing in pneumonia: The current landscape and future potential

Stephen Poole et al. J Infect. 2020 Jan.

Abstract

Community acquired pneumonia (CAP), hospital-acquired pneumonia (HAP) and ventilator associated pneumonia (VAP) are all associated with significant mortality and cause huge expense to health care services around the world. Early, appropriate antimicrobial therapy is crucial for effective treatment. Syndromic diagnostic testing using novel, rapid multiplexed molecular platforms represents a new opportunity for rapidly targeted antimicrobial therapy to improve patient outcomes and facilitate antibiotic stewardship. In this article we review the currently available testing platforms and discuss the potential benefits and pitfalls of rapid testing in pneumonia.

Keywords: Community acquired pneumonia (CAP); Hospital acquired pneumonia (HAP); Molecular diagnostics; Pneumonia; Point-of-care testing; Rapid diagnostics; Ventilator associated pneumonia (VAP).

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Conflict of interest statement

Poole, S. - Declarations of interest: none. Clark, T.W. has received speaker fees, reimbursement for travel and honoraria from Biofire LLC and BioMerieux and has also received equipment and consumables from these companies for the purposes of independent research. No commercial entities had any input into this manuscript.

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