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Meta-Analysis
. 2019 Dec;39(12):6431-6441.
doi: 10.21873/anticanres.13857.

Microsatellite Instability and Survival in Stage II Colorectal Cancer: A Systematic Review and Meta-analysis

Fausto Petrelli  1 , Michele Ghidini  2 , Mary Cabiddu  3 , Ezio Pezzica  4 , Daniela Corti  4 , Luca Turati  5 , Antonio Costanzo  5 , Antonio Varricchio  5 , Antonio Ghidini  6 , Sandro Barni  3 , Gianluca Tomasello  7
Affiliations
Meta-Analysis

Microsatellite Instability and Survival in Stage II Colorectal Cancer: A Systematic Review and Meta-analysis

Fausto Petrelli et al. Anticancer Res. 2019 Dec.

Abstract

Background/aim: About 15-20% of colorectal cancers (CRCs) have deficiency in a mismatch repair (MMR) protein. MMR has a high level of microsatellite instability (MSI-H). We have conducted this review and meta-analysis to determine the prognostic role of MSI-H status in stage II CRC.

Materials and methods: We searched PubMed, EMBASE, The Cochrane Library, Web of Science, and SCOPUS for studies reporting data on overall survival (OS) and disease-free or relapse-free survival (DFS or RFS) for MSI-H compared to microsatellite stable (MSS) CRC.

Results: A total of 39 studies were analysed, including 12,110 patients. MSI-H status was associated with a significantly reduced risk of death (HR=0.64, 95%CI=0.52-0.8, p<0.01) and relapse (HR=0.59, 95%CI=0.45-0.77, p<0.01) in stage II CRC.

Conclusion: MSI-H represents an important prognostic determinant in stage II CRC and may be considered when estimating the risk of recurrence in stage II CRC.

Keywords: Colorectal cancer; meta-analysis; microsatellite instability; prognosis; review; stage II.

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