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Comment
. 2019 Dec 6;4(42):eaaz6821.
doi: 10.1126/sciimmunol.aaz6821.

IFN-γ: The T cell's license to kill stem cells in the inflamed intestine

Kai Kretzschmar  1 , Hans Clevers  2   3
Affiliations
Comment

IFN-γ: The T cell's license to kill stem cells in the inflamed intestine

Kai Kretzschmar et al. Sci Immunol. .

Abstract

IFN-γ produced by T cells directly induces intestinal stem cell death upon inflammation-induced intestinal injury (see the related Research Article by Takashima et al.).

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  • T cell-derived interferon-γ programs stem cell death in immune-mediated intestinal damage.
    Takashima S, Martin ML, Jansen SA, Fu Y, Bos J, Chandra D, O'Connor MH, Mertelsmann AM, Vinci P, Kuttiyara J, Devlin SM, Middendorp S, Calafiore M, Egorova A, Kleppe M, Lo Y, Shroyer NF, Cheng EH, Levine RL, Liu C, Kolesnick R, Lindemans CA, Hanash AM. Takashima S, et al. Sci Immunol. 2019 Dec 6;4(42):eaay8556. doi: 10.1126/sciimmunol.aay8556. Sci Immunol. 2019. PMID: 31811055 Free PMC article.

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