Th9 cells in allergic diseases: A role for the microbiota?

Abstract

Since their discovery about 10 years ago, Th9 cells have been increasingly linked to allergic pathologies. Within this review, we summarize the current knowledge on associations between Th9 cells and allergic diseases and acknowledge Th9 cells as important targets in future treatment of allergic diseases. However, until today, it is not fully understood how these Th9 cell responses are modulated. We describe current literature suggesting that these Th9 cell responses might be stimulated by microbial species such as Staphylococcus aureus and Candida albicans, while on the other hand, microbial and dietary compounds such as retinoic acid (RA), butyrate and vitamin D show suppressive capacity on allergy-related Th9 responses. By reviewing this recent research, we provide new insights into the modulating capacity of the microbiota on Th9 cell responses. Consequently, microbial and dietary factors may be used as innovative tools to target Th9 cells in the treatment of allergic diseases. However, further research is needed to elucidate the mechanisms behind these interactions in order to translate this knowledge into clinical allergy settings.

Keywords: T helper 9 cells; allergy; microbiota.

Figure 1

Schematic representation of the current knowledge on associations between microbial species as well as microbial and dietary metabolites and Th9 cells. Inhibiting effects on Th9 cells are represented by green lines, while stimulating effects are indicated with red arrows. Origin site and/or localization of the microbes and microbial and dietary metabolites is shown. (Figure made with BioRender)