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Review
. 2020 Apr;467(1-2):1-12.
doi: 10.1007/s11010-019-03667-9. Epub 2019 Dec 7.

ROS and diseases: role in metabolism and energy supply

Shenshu Yang  1 , Gaojian Lian  2
Affiliations
Review

ROS and diseases: role in metabolism and energy supply

Shenshu Yang et al. Mol Cell Biochem. 2020 Apr.

Erratum in

Abstract

Researches dedicated to reactive oxygen species (ROS) had been performed for decades, yet the outcomes remain controversial. With the relentless effort of studies, researchers have explored the role of ROS in biosystem and various diseases. ROS are beneficial for biosystem presenting as signalling molecules and enhancing immunologic defence. However, they also have harmful effects such as causing tissue and organ damages. The results are controversial in studies focusing on ROS and ROS-related diseases by regulating ROS with inhibitors or promotors. These competing results hindered the process for further investigation of the specific mechanisms lying behind. The opinions presented in this review interpret the researches of ROS from a different dimension that might explain the competing results of ROS introduced so far from a broader perspective. This review brings a different thinking to researchers, with the neglected features and potentials of ROS, to relate their works with ROS and to explore the mechanisms between their subject and ROS.

Keywords: Diseases; Homeostasis; Metabolism; Pathology; ROS.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Generation of ROS in mitochondria
See this image and copyright information in PMC

References

    1. Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007;87(1):245–313. doi: 10.1152/physrev.00044.2005. - DOI - PubMed
    1. Nathan C, Cunningham-Bussel A. Beyond oxidative stress: an immunologist’s guide to reactive oxygen species. Nat Rev Immunol. 2013;13(5):349–361. doi: 10.1038/nri3423. - DOI - PMC - PubMed
    1. Shadel GS, Horvath TL. Mitochondrial ROS signaling in organismal homeostasis. Cell. 2015;163(3):560–569. doi: 10.1016/j.cell.2015.10.001. - DOI - PMC - PubMed
    1. Prosser BL, Ward CW, Lederer WJ. X-ROS signaling: rapid mechano-chemo transduction in heart. Science. 2011;333(6048):1440–1445. doi: 10.1126/science.1202768. - DOI - PubMed
    1. West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, Walsh MC, Choi Y, Shadel GS, Ghosh S. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature. 2011;472(7344):476–480. doi: 10.1038/nature09973. - DOI - PMC - PubMed

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