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Comment
. 2019 Dec;5(12):756-759.
doi: 10.1016/j.trecan.2019.10.004. Epub 2019 Nov 4.

Metronomic Maintenance Therapy for Rhabdomyosarcoma

Nicolas André  1 , Nadège Corradini  2 , Yuval Shaked  3
Affiliations
Comment

Metronomic Maintenance Therapy for Rhabdomyosarcoma

Nicolas André et al. Trends Cancer. 2019 Dec.

Abstract

In a recent article, Bisogno et al. reported in a randomized trial that addition of metronomic maintenance therapy (MMT) with vinorelbine plus cyclophosphamide for children with rhabdomyosarcoma resulted in a significant increase in overall and event-free survival. Although the mechanism of action remains to be fully elucidated, this study paves the way for further evaluation of MMT as a potential therapeutic strategy in pediatric patients with high-risk disease.

Keywords: angiogenesis; chemotherapy; immunity; maintenance; metronomic; microenvironment; rhabdomyosarcoma.

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