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. 1988 Nov 7;239(2):227-32.
doi: 10.1016/0014-5793(88)80922-0.

Islet amyloid polypeptide: identification and chromosomal localization of the human gene

S Mosselman  1 , J W Höppener, J Zandberg, A D van Mansfeld, A H Geurts van Kessel, C J Lips, H S Jansz
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Free article

Islet amyloid polypeptide: identification and chromosomal localization of the human gene

S Mosselman et al. FEBS Lett. .
Free article

Abstract

Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy-terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy-terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.

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