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. 2019 Dec;31(6):505-522.
doi: 10.1521/aeap.2019.31.6.505.

Mapping the Study Characteristics and Topics of HIV Pre-Exposure Prophylaxis Research Literature: A Scoping Review

Emiko Kamitani  1 , Yuko Mizuno  1 , Megan Wichser  1 , Adebukola H Adegbite  1 , Julia B DeLuca  1 , Darrel H Higa  1
Affiliations

Mapping the Study Characteristics and Topics of HIV Pre-Exposure Prophylaxis Research Literature: A Scoping Review

Emiko Kamitani et al. AIDS Educ Prev. 2019 Dec.

Abstract

Since WHO released the first PrEP guidance in 2012, the PrEP research literature has rapidly increased, but PrEP uptake is still low. To identify research gaps, this scoping review describes study characteristics, identifies populations, and maps study topics in PrEP publications. We identified 561 PrEP primary studies published in English between 2006 and 2018. The most commonly used study design was cross-sectional. Almost half of studies were conducted in non-U.S. countries and focused on men who have sex with men. We mapped study topics using five categories. The most studied category was Potential PrEP user/prescriber (41.3%) followed by Considerations while on PrEP (28.2%), PrEP efficacy and safety (20.9%), Cost-effectiveness or economic evaluation (5.2%), and Methods of and experiences with PrEP clinical trials (4.2%). Although the PrEP literature has dramatically increased, some research areas (e.g., PrEP awareness in non-U.S. countries, intervention studies to promote PrEP use) and populations (e.g., Black women) are still understudied.

Keywords: HIV; pre-exposure prophylaxis; research disparity; scoping review.

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Figures

FIGURE 1.
FIGURE 1.
PRISMA flowchart for screening.
FIGURE 2.
FIGURE 2.
Number of studies by category of study topic and published year (2006–2017) (N = 561).
FIGURE 3A.
FIGURE 3A.
Type of study design by category of study topic.
FIGURE 3B.
FIGURE 3B.
Country of study by category of study topic.
FIGURE 3C.
FIGURE 3C.
Overall study participant characteristics.
See this image and copyright information in PMC

References

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