Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases

Wei He¹, Neha Kapate², C Wyatt Shields 4th³, Samir Mitragotri⁴

Affiliations

¹ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
² John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
⁴ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: mitragotri@seas.harvard.edu.

PMID: 31816357
DOI: 10.1016/j.addr.2019.12.001

Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases

Wei He et al. Adv Drug Deliv Rev. 2020.

. 2020:165-166:15-40.

doi: 10.1016/j.addr.2019.12.001. Epub 2019 Dec 6.

Authors

Wei He¹, Neha Kapate², C Wyatt Shields 4th³, Samir Mitragotri⁴

Affiliations

¹ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
² John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
³ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
⁴ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: mitragotri@seas.harvard.edu.

PMID: 31816357
DOI: 10.1016/j.addr.2019.12.001

Abstract

Macrophages play a key role in defending against foreign pathogens, healing wounds, and regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which enables macrophages to respond to subtle cues in tightly coordinated ways. However, when this coordination is disrupted, macrophages can aid the progression of numerous diseases, including cancer, cardiovascular disease, and autoimmune disease. The central link between these disorders is aberrant macrophage polarization, which misguides their functional programs, secretory products, and regulation of the surrounding tissue microenvironment. As a result of their important and deterministic roles in both health and disease, macrophages have gained considerable attention as targets for drug delivery. Here, we discuss the role of macrophages in the initiation and progression of various inflammatory diseases, summarize the leading drugs used to regulate macrophages, and review drug delivery systems designed to target macrophages. We emphasize strategies that are approved for clinical use or are poised for clinical investigation. Finally, we provide a prospectus of the future of macrophage-targeted drug delivery systems.

Keywords: Autoimmune disease; Cardiovascular disease; Drug delivery; Inflammation; Macrophages; Solid tumors.

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Conflict of interest statement

Declaration of Competing Interest S.M. is a shareholder of, consultant to, and recipient of research grants from several drug delivery, pharmaceutical and biotechnology companies, including those active in the general area of research discussed in this article. S.M. is the inventor on several patents in the field of drug delivery and formulations that are owned by their current or former employers. The views presented here should not be considered as endorsements of any specific product or company.

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Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases

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Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases

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