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Review
. 2019 Dec 4;10(12):1008.
doi: 10.3390/genes10121008.

The Roles of Hypoxia-Inducible Factors and Non-Coding RNAs in Gastrointestinal Cancer

Hyun-Soo Cho  1 , Tae-Su Han  1 , Keun Hur  2 , Hyun Seung Ban  1
Affiliations
Review

The Roles of Hypoxia-Inducible Factors and Non-Coding RNAs in Gastrointestinal Cancer

Hyun-Soo Cho et al. Genes (Basel). .

Abstract

Hypoxia-inducible factors (HIFs) are transcription factors that play central roles in cellular responses against hypoxia. In most cancers, HIFs are closely associated with tumorigenesis by regulating cell survival, angiogenesis, metastasis, and adaptation to the hypoxic tumor microenvironment. Recently, non-coding RNAs (ncRNAs) have been reported to play critical roles in the hypoxic response in various cancers. Here, we review the roles of hypoxia-response ncRNAs in gastrointestinal cancer, with a particular focus on microRNAs and long ncRNAs, and discuss the functional relationships and regulatory mechanisms between HIFs and ncRNAs.

Keywords: gastrointestinal cancer; hypoxia; hypoxia-inducible factor; microRNA; non-coding RNA.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Summary for HIF-related ncRNAs in gastrointestinal cancers.
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