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Review
. 2019 Dec 6;24(24):4469.
doi: 10.3390/molecules24244469.

Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development

Lúcio Ricardo Leite Diniz  1 , Marilia Trindade de Santana Souza  1 , Joice Nascimento Barboza  2 , Reinaldo Nóbrega de Almeida  3 , Damião Pergentino de Sousa  2
Affiliations
Review

Antidepressant Potential of Cinnamic Acids: Mechanisms of Action and Perspectives in Drug Development

Lúcio Ricardo Leite Diniz et al. Molecules. .

Abstract

Depression is a health problem that compromises the quality of life of the world's population. It has different levels of severity and a symptomatic profile that affects social life and performance in work activities, as well as a high number of deaths in certain age groups. In the search for new therapeutic options for the treatment of this behavioral disorder, the present review describes studies on antidepressant activity of cinnamic acids, which are natural products found in medicinal plants and foods. The description of the animal models used and the mechanisms of action of these compounds are discussed.

Keywords: behavioral disorders; depression; forced swim test; natural products; phenolic acids; phenylpropanoids; plants; tail suspension test.

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Conflict of interest statement

The authors declare no conflict of interest

Figures

Figure 1
Figure 1
Mechanisms of action of antidepressant drugs.
Figure 2
Figure 2
Chemical structure of cinnamic acid.
Figure 3
Figure 3
Chemical structures of antidepressant cinnamic acids.
Figure 4
Figure 4
Antidepressant action of cinnamic acids.
See this image and copyright information in PMC

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