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. 2019 Dec 6;16(24):4970.
doi: 10.3390/ijerph16244970.

Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis

Elvin T Ng  1   2 , Russell Z Ang  2 , Bach X Tran  3   4 , Cyrus S Ho  5 , Zhisong Zhang  1   6 , Wanqiu Tan  6   7 , Yu Bai  1 , Min Zhang  1 , Wilson W Tam  8 , Roger C Ho  1   6   9   10
Affiliations

Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis

Elvin T Ng et al. Int J Environ Res Public Health. .

Abstract

: The purpose of our study was to carry out a meta-analysis of current literature to determine whether total mastectomy and breast-conserving surgery induce different outcomes in quality of life, based on the breast-cancer-specific module of the European Organizaation for Research and Treatment of Cancer core questionnaire (EORTC QLQ-BR23) used postoperatively. A systematic literature search of PubMed and EMBASE was conducted. Observational clinical studies that compared the quality of life in different surgery groups and presented empirical findings were selected. Six studies met the inclusion criteria. Breast-conserving surgery has statistically significant better outcomes than mastectomy in three of the eight outcomes measured in the EORTC QLQ-BR23, namely body image (standard mean difference, SMD = 1.742, 95% CI 0.579-2.905, p = 0.003), future perspective (SMD = 0.606, 95% CI 0.075-1.138, p = 0.025) and systemic therapy side effects (SMD = -0.641, 95% CI 0.101-1.181, p = 0.020). Our study highlighted that breast-conserving surgery was preferred over mastectomy because breast-conserving surgery leads to better outcomes in body image, future perspectives and less systemic side effects.

Keywords: breast cancer; breast conserving; individualised patient profiles; mastectomy; meta-analysis; patient stratification; phenotyping; quality of life.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the result.

Figures

Figure 1
Figure 1
Process of study selection.
Figure 2
Figure 2
Forest plot showing the standardised mean difference of the body image score in patients who underwent mastectomy vs. BCS.
Figure 3
Figure 3
Forest plot showing the standardised mean difference of the future perspective score in patients who underwent mastectomy vs. BCS.
Figure 4
Figure 4
Forest plot showing the standardised mean difference of the systemic therapy side effects score in patients who underwent mastectomy vs. BCS.
See this image and copyright information in PMC

References

    1. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2016. CA A Cancer J. Clin. 2016;66:7–30. doi: 10.3322/caac.21332. - DOI - PubMed
    1. Christiansen P., Carstensen S.L., Ejlertsen B., Kroman N., Offersen B., Bodilsen A., Jensen M.B. Breast conserving surgery versus mastectomy: Overall and relative survival—A population based study by the Danish Breast Cancer Cooperative Group (DBCG) Acta Oncol. 2017;57:19–25. doi: 10.1080/0284186X.2017.1403042. - DOI - PubMed
    1. Vila J., Gandini S., Gentilini O. Overall survival according to type of surgery in young (≤40 years) early breast cancer patients: A systematic meta-analysis comparing breast-conserving surgery versus mastectomy. Breast. 2015;24:175–181. doi: 10.1016/j.breast.2015.02.002. - DOI - PubMed
    1. Sinnadurai S., Kwong A., Hartman M., Hartman Tan E.Y., Bhoo-Pathy N.T., Dahlui M., See M.H., Yip C.H., Taib N.A., Bhoo-Pathy N., et al. Breast-conserving surgery versus mastectomy in young women with breast cancer in Asian settings. BJS Open. 2018;3:48–55. doi: 10.1002/bjs5.50111. - DOI - PMC - PubMed
    1. Zhang C., Hu G., Biskup E., Qiu X., Zhang H., Zhang H. Depression Induced by Total Mastectomy, Breast Conserving Surgery and Breast Reconstruction: A Systematic Review and Meta-analysis. World J. Surg. 2018;42:2076–2085. doi: 10.1007/s00268-018-4477-1. - DOI - PubMed

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