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Case Reports
. 2019 Dec 8;12(12):e232065.
doi: 10.1136/bcr-2019-232065.

Recurrent leiomyoma of the vulva mimicking peripheral nerve sheath tumour

Keerthana Kothandaraman  1 , Gowri Dorairajan  1 , Murali Subbaiah  1 , L N Dorairajan  2 , Bhawana A Badhe  3 , Anish Keepanasseril  4
Affiliations
Case Reports

Recurrent leiomyoma of the vulva mimicking peripheral nerve sheath tumour

Keerthana Kothandaraman et al. BMJ Case Rep. .

Abstract

Leiomyoma, a benign monoclonal tumour, is very rarely found in extrauterine sites, especially in the vulval region. Histopathology of the soft tissue tumours affecting this region is similar and immunohistochemistry (IHC) may be essential to confirm the diagnosis. We report a case of a 63-year-old postmenopausal woman who presented with a recurrent vulval mass involving the clitoris and left labia majora with suspected urethral involvement. Although the wedge biopsy was reported as peripheral nerve sheath tumour, staining with smooth muscle actin clinched the diagnosis of leiomyoma, highlighting the importance of IHC for diagnosis.

Keywords: obstetrics and gynaecology; pathology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Leiomyoma of the vulva involving the clitoris and labia majora,(A) extending upto urethra. Arrow points towards the urethral orifice (B). H&E stain ×40 magnification (C)—section showing interlacing bundles of smooth muscle cells with elongated vesicular nucleus with moderate pink cytoplasm. No mitosis or necrosis was seen. Immunohistochemistry for smooth muscle actin(SMA) antibody ×40 magnification (D)—the tumour cells are positive for SMA as shown in the figure cytoplasmic positivity and (E) postoperative picture of the perineal region.
See this image and copyright information in PMC

References

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