Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Dec;56(12):3316-9.
doi: 10.1128/iai.56.12.3316-3319.1988.

Hormonal modulation of sex differences in resistance to Leishmania major systemic infections

B A Mock  1 , C A Nacy
Affiliations

Hormonal modulation of sex differences in resistance to Leishmania major systemic infections

B A Mock et al. Infect Immun. 1988 Dec.

Abstract

Differences in susceptibility to intravenously inoculated Leishmania major were observed in male and female mice of the BALB/cAnPt, DBA/2N, and DBA/2J strains and (BALB/cAnPt x DBA/2N)F1 hybrids. In all cases, males had significantly higher liver parasite burdens than females. Orchidectomy of BALB/c males resulted in a 20% decrease in the number of parasites in the liver compared with either normal or sham-gonadectomized controls. Additionally, testosterone treatment of female BALB/c mice resulted in an 88% increase in the number of liver amastigotes. These results suggest that the hormone testosterone can modulate systemic L. major infections in BALB/c mice.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Immunogenetics. 1985;21(4):385-95 - PubMed
    1. Science. 1985 Jan 18;227(4684):257-61 - PubMed
    1. Cell. 1984 Apr;36(4):805-12 - PubMed
    1. J Parasitol. 1947 Oct;33(5):399-404 - PubMed
    1. J Immunol. 1984 Feb;132(2):656-61 - PubMed

Publication types