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Review
. 2019 Dec;86(12):807-814.
doi: 10.3949/ccjm.86a.19005.

Beyond depression: Other uses for tricyclic antidepressants

Joanne Schneider  1 , Mary Patterson  1 , Xavier F Jimenez  2
Affiliations
Free article
Review

Beyond depression: Other uses for tricyclic antidepressants

Joanne Schneider et al. Cleve Clin J Med. 2019 Dec.
Free article

Abstract

Tricyclic antidepressants (TCAs) were originally designed and marketed for treating depression, but over time they have been applied to a variety of conditions, mostly off-label. TCAs can serve as first-line or augmenting drugs for neuropathic pain, headache, migraine, gastrointestinal syndromes, fibromyalgia, pelvic pain, insomnia, and psychiatric conditions other than depression. This article reviews pharmacology, dosing, and safety considerations for these uses.

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Comment in

  • Off-label and oft-prescribed.
    Mandell BF. Mandell BF. Cleve Clin J Med. 2019 Dec;86(12):766-767. doi: 10.3949/ccjm.86b.12019. Cleve Clin J Med. 2019. PMID: 31821134 No abstract available.

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