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Comment
. 2019 Dec 10:8:e52959.
doi: 10.7554/eLife.52959.

Modelling survival

Teresa A Zimmers  1   2   3   4   5   6   7 , Leonidas G Koniaris  1   5   6   7
Affiliations
Comment

Modelling survival

Teresa A Zimmers et al. Elife. .

Abstract

A new mouse model of sepsis can reproduce the long-term muscle weakness seen in patients who survive this life-threatening illness.

Keywords: chronic critical illness; human biology; immunology; inflammation; medicine; mitochondria; mouse; muscle; post-intensive care syndrome; sepsis.

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Conflict of interest statement

TZ, LK No competing interests declared

Figures

Figure 1.
Figure 1.. A mouse model for studying sepsis survival.
Sepsis is a life-threatening illness that occurs when the immune system overreacts to an injury or infection. Patients with early diagnosis of sepsis who are treated in an intensive care unit (ICU) have a much greater chance of survival (green arrow). However, a significant number of survivors suffer from long-term debilitating effects (blue arrow) and late mortality (red arrow). To better understand how to treat these long-term effects, Owen et al. have developed a mouse model that replicates the treatment outcomes of patients who had survived sepsis: 16-month-old mice were given an injury that induced sepsis and then given the same fluids and drugs patients would receive when in the ICU. These mice exhibited the long-term muscle weakness that commonly occurs in sepsis survivors.
See this image and copyright information in PMC

Comment on

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