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. 2020 Jan 30;100(1):adv00042.
doi: 10.2340/00015555-3390.

An Intimate Relationship Between Intralesional Depigmentation and Peripheral Nervous System in Lichen Simplex Chronicus

Toshio Ichiki  1 , Kazunari Sugita, Masutaka Furue, Osamu Yamamoto
Affiliations

An Intimate Relationship Between Intralesional Depigmentation and Peripheral Nervous System in Lichen Simplex Chronicus

Toshio Ichiki et al. Acta Derm Venereol. .
No abstract available

Keywords: leukoderma; lichen simplex chronicus; lichen vidal; nerve growth factor; neurodermatitis; neuroimmune connection.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Immunohistochemical staining for (A, B) S-100 protein and Melan-A, (C) pan-neuronal marker PGP 9.5, and (D) nerve growth factor (NGF). (A, B) The numbers of S-100 protein-positive cells and Melan-A-positive cells are significantly decreased in leukoderma areas compared with non-leukoderma areas. (C) The number and length of nerve fibers are significantly decreased in leukoderma areas. (D) The NGF expression calculated by histoscore is significantly lower in leukoderma areas. (E, F). There was strong correlation between number of melanocytes and NGF histoscore (correlation function: r=0.60) and strong correlation between number of melanocytes and number of peripheral neurons (r=0.69).
See this image and copyright information in PMC

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