Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jun;33(3):423-430.
doi: 10.1111/jhn.12726. Epub 2019 Dec 11.

Metabolic bone diseases in intestinal failure

P J Allan  1 , S Lal  2   3
Affiliations
Review

Metabolic bone diseases in intestinal failure

P J Allan et al. J Hum Nutr Diet. 2020 Jun.

Abstract

Metabolic bone diseases are a group of conditions that are common complications in patients with intestinal failure. These may occur as a result of the underlying condition, leading to intestinal failure, particularly inflammatory conditions such as Crohn's disease and their associated treatments including corticosteroids. Malabsorption, as a result of a loss of enterocyte mass or gut function, of many nutrients, including vitamin D, may further compound metabolic bone problems, and there has been historical contamination of parenteral nutrition with aluminium that has prevented normal bone metabolism contributing to osteoporosis. This review looks at the diagnosis and current management of bone health in patients with intestinal failure.

Keywords: fracture; home parenteral nutrition; intestinal failure; metabolic bone disease; osteomalacia; osteoporosis.

PubMed Disclaimer

References

    1. Pironi L, Arends J, Baxter J et al. (2014) ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults. Clin Nutr 34, 171-80.
    1. Brandt CF, Hvistendahl M, Naimi RM et al. (2017) Home parenteral nutrition in adult patients with chronic intestinal failure: the evolution over 4 decades in a tertiary referral center. JPEN J Parenter Enteral Nutr 41, 1178-1187.
    1. Dibb M, Soop M, Teubner A et al. (2017) Survival and nutritional dependence on home parenteral nutrition: Three decades of experience from a single referral centre. Clin Nutr 36, 570-576.
    1. Raman M, Gramlich L, Whittaker S et al. (2007) Canadian home total parenteral nutrition registry: preliminary data on the patient population. Can J Gastroenterol 21, 643-648.
    1. Pironi L, Konrad D, Brandt C et al. (2018) Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey. Clin Nutr 37, 728-738.

Publication types

MeSH terms