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Review
. 2020 Jun;15(6):1025-1026.
doi: 10.4103/1673-5374.270304.

The extended renin-angiotensin system: a promising target for traumatic brain injury therapeutics

Zachary C Janatpour  1 , Aviva J Symes  1
Affiliations
Review

The extended renin-angiotensin system: a promising target for traumatic brain injury therapeutics

Zachary C Janatpour et al. Neural Regen Res. 2020 Jun.
No abstract available

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Effects of RAS-modulating ligands on TBI. Various ligands that act on receptors of the RAS and/or eRAS reduce sequelae of TBI in rodent models. Downward green arrows depict a ligand’s documented ability to reduce a particular sequela of TBI in rodents. Question marks depict unknown associations between a ligand and a particular sequela of TBI in rodents. eRAS: Extended renin-angiotensin system; RAS: renin-angiotensin system; TBI: traumatic brain injury.
See this image and copyright information in PMC

References

    1. GBD 2016 Dementia Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:88–106. - PMC - PubMed
    1. Jackson L, Eldahshan W, Fagan SC, Ergul A. Int J Mol Sci. 2018. Within the brain: The renin angiotensin system. doi: 10.3390/ijms19030876. - PMC - PubMed
    1. Janatpour ZC, Korotcov A, Bosomtwi A, Dardzinski BJ, Symes AJ. Subcutaneous administration of angiotensin-(1-7) improves recovery after traumatic brain injury in mice. J Neurotrauma. 2019 doi: 101089/neu20196376. - PubMed
    1. Joseph JP, Mecca AP, Regenhardt RW, Bennion DM, Rodríguez V, Desland F, Patel NA, Pioquinto DJ, Unger T, Katovich MJ, Steckelings UM, Sumners C. The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke. Neuropharmacology. 2014;81:134–141. - PMC - PubMed
    1. McCarthy CA, Vinh A, Callaway JK, Widdop RE. Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke. Stroke. 2009;40:1482–1489. - PubMed