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. 2019 Nov 21:7:342.
doi: 10.3389/fbioe.2019.00342. eCollection 2019.

A Systematic Review and Meta-Analysis of Clinical Effectiveness and Safety of Hydrogel Dressings in the Management of Skin Wounds

Lijun Zhang  1 , Hanxiao Yin  1 , Xun Lei  2 , Johnson N Y Lau  3 , Mingzhou Yuan  1 , Xiaoyan Wang  1 , Fangyingnan Zhang  1 , Fei Zhou  1 , Shaohai Qi  1 , Bin Shu  1 , Jun Wu  1
Affiliations

A Systematic Review and Meta-Analysis of Clinical Effectiveness and Safety of Hydrogel Dressings in the Management of Skin Wounds

Lijun Zhang et al. Front Bioeng Biotechnol. .

Abstract

The purpose of this systematic review and meta-analysis is to assess the clinical effectiveness and safety of the medical hydrogel dressings used in skin wounds and therefore to weight the evidence for their clinical application. PubMed/Medline (1980-2019), Cochrane Library (1980-2019), ClinicalTrials.gov, Cochrane CENTRAL, Chinese Journal Full-text Database (CNKI, 1994-2019), and China Biomedy Medicine disc (CBM, 1978-2019), Chinese Scientific Journal Database (VIP, 1989-2019), and Wanfang Database (WFDATA, 1980-2019) were searched to identify relevant clinical trials and studies. Forty-three studies that assessed hydrogel vs. non-hydrogel dressings were identified. Compared to the latter, hydrogel dressings associated with a significantly shortened healing time of degree II burn (superficial and deep) wounds, diabetic foot ulcers, traumatic skin injuries, radioactive skin injuries, dog bites, and body surface ulcers. In addition, hydrogel dressing obviously increased the cure rate of diabetic foot ulcers, surgical wounds, dog bites, and body surface ulcers. Moreover, hydrogel dressing significantly relieved pain in degree II burn (superficial and deep) wounds, traumatic skin injuries, and laser treatment-induced wounds. However, no significant differences obtained between hydrogel and non-hydrogel dressings in the healing time of surgical wounds, the cure rate of inpatients' pressure ulcers, and phlebitis ulcers. This comprehensive systematic review and meta-analysis of the available evidence reveals that the application of hydrogel dressings advances the healing of various wound types and effectively alleviates the pain with no severe adverse reactions. These results strongly indicate that hydrogel products are effective and safe in wound management.

Keywords: hydrogel; meta-analysis; pain relief; systematic review; wound dressing; wound healing.

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Figures

Figure 1
Figure 1
PRISMA flow diagram for inclusion or exclusion of studies used for systematic review.
Figure 2
Figure 2
Comparative meta-analysis of the healing times of degree-II superficial (A) and degree-II deep (B) burn wounds.
Figure 3
Figure 3
Comparative meta-analysis of WHO pain ratings of burn wounds.
Figure 4
Figure 4
Comparative meta-analysis of VAS pain scores of degree-II superficial (A) and deep (B) burn wounds.
Figure 5
Figure 5
Comparative meta-analysis of wound healing times of diabetic foot ulcers.
Figure 6
Figure 6
Comparative meta-analysis of wound cure rates of diabetic foot ulcers.
Figure 7
Figure 7
Comparative meta-analysis of healing times of traumatic skin injuries.
Figure 8
Figure 8
Comparative meta-analysis of WHO pain ratings of traumatic skin injuries.
Figure 9
Figure 9
Comparative meta-analysis of healing times (A) and cure rates (B) of surgical wounds.
Figure 10
Figure 10
Comparative meta-analysis of cure rates of inpatients' pressure ulcers.
Figure 11
Figure 11
Comparative meta-analysis of healing times of radioactive skin injuries.
Figure 12
Figure 12
Comparative meta-analysis of cure rates of phlebitis ulcers.
Figure 13
Figure 13
Comparative meta-analysis of the incidence rates of adverse reactions of burn wound-affected patients.
See this image and copyright information in PMC

References

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