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Clinical Trial
. 2020 Jul 4;18(2):325-330.
doi: 10.3290/j.ohpd.a43360.

Three-Month Effect of Silver Diamine Fluoride (SDF) in Salivary Levels of Streptococcus Mutans in Children. An Exploratory Trial

Marta Diogo Garrastazu, Ingrid Fernandes Mathias-Santamaria, Rafael Santos Rocha, Michele Baffi Diniz, Taciana Marco Ferraz Caneppele, Eduardo Bresciani
Clinical Trial

Three-Month Effect of Silver Diamine Fluoride (SDF) in Salivary Levels of Streptococcus Mutans in Children. An Exploratory Trial

Marta Diogo Garrastazu et al. Oral Health Prev Dent. .

Abstract

Purpose: The aim of this exploratory trial was to compare the 3-month effect of two antimicrobials on the salivary levels of Streptococcus mutans (SM) in children.

Materials and methods: Ninety school children aged 6-10 years participated. They were divided into two groups according to treatment used: 1% chlorhexidine gel (CHX) or 30% silver diamine fluoride (SDF). Saliva for SM colony forming unit (CFU)/ml counting was harvested in four periods: baseline (prior to antimicrobials); P1 (24 h after antimicrobial therapy); P30 (30 days after antimicrobial therapy); and P90 (90 days after antimicrobial therapy). CFU/ml data was submitted to repeated measures by analysis of variance (ANOVA).

Results: Only the time factor influenced the results (p <0.001), with a reduction of SM for all evaluated periods in comparison to the baseline. No influence of antimicrobials or interactions of factors were detected (p >0.05). P30 presented the lowest levels of SM and at P90, SM levels were similar to P1 but still lower than the baseline observations. SDF and CHX presented a similar effect on SM within each period of evaluation (p = 0.65).

Conclusion: It was concluded that 30% SDF presents similar antimicrobial effects as 1% CHX over time. SDF might be used as an adjunctive therapy for controlling dental caries in children.

Keywords: Streptococcus mutans; dental caries; silver diamine fluoride.

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Figures

Fig 1
Fig 1
Graph with distribution of detected salivary Streptococcus mutans (log transformed CFU/ml and 0.95 confidence interval) according to the assessed periods.
See this image and copyright information in PMC

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