Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Apr;34(4):729-741.
doi: 10.1002/ptr.6573. Epub 2019 Dec 11.

A review on gentisic acid as a plant derived phenolic acid and metabolite of aspirin: Comprehensive pharmacology, toxicology, and some pharmaceutical aspects

Farshad Abedi  1 , Bibi Marjan Razavi  2   3 , Hossein Hosseinzadeh  3   4
Affiliations
Review

A review on gentisic acid as a plant derived phenolic acid and metabolite of aspirin: Comprehensive pharmacology, toxicology, and some pharmaceutical aspects

Farshad Abedi et al. Phytother Res. 2020 Apr.

Abstract

Beneficial therapeutic effects of phenolic acids have been proven in various research projects including in vivo and in vitro studies. Gentisic acid (GA) is a phenolic acid that has been associated with useful effects on human health, such as antiinflammatory, antigenotoxic, hepatoprotective, neuroprotective, antimicrobial, and especially antioxidant activities. It is an important metabolite of aspirin and also widely distributed in plants as a secondary plant product such as Gentiana spp., Citrus spp., Vitis vinifera, Pterocarpus santalinus, Helianthus tuberosus, Hibiscus rosa-sinensis, Olea europaea, and Sesamum indicum and in fruits such as avocados, batoko plum, kiwi fruits, apple, bitter melon, black berries, pears, and some mushrooms. This study was undertaken to review the pharmacological effects, pharmacokinetic properties as well as toxicity and pharmaceutical applications of GA.

Keywords: 2,5-dihydroxybenzoic acid; antioxidant; aspirin; gentisic acid; phenolic acids.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

REFERENCES

    1. Altinoz, M. A., Elmaci, I., Cengiz, S., Emekli-Alturfan, E., & Ozpinar, A. (2018). From epidemiology to treatment: Aspirin's prevention of brain and breast-cancer and cardioprotection may associate with its metabolite gentisic acid. Chemico-Biological Interactions, 291, 29-39.
    1. Asada, M., Shinomiya, M., Suzuki, M., Honda, E., Sugimoto, R., Ikekita, M., & Imamura, T. (2009). Glycosaminoglycan affinity of the complete fibroblast growth factor family. Biochimica et Biophysica Acta (BBA) - General Subjects, 1790(1), 40-48.
    1. Ashidate, K., Kawamura, M., Mimura, D., Tohda, H., Miyazaki, S., Teramoto, T., … Hirata, Y. (2005). Gentisic acid, an aspirin metabolite, inhibits oxidation of low-density lipoprotein and the formation of cholesterol ester hydroperoxides in human plasma. European Journal of Pharmacology, 513(3), 173-179. https://doi.org/10.1016/j.ejphar.2005.03.012
    1. Awtry, E. H., & Loscalzo, J. (2000). Aspirin. Circulation, 101(10), 1206-1218. https://doi.org/10.1161/01.CIR.101.10.1206
    1. Bahar, F. G., & Imai, T. (2013). Aspirin hydrolysis in human and experimental animal plasma and the effect of metal cations on hydrolase activities. Drug Metabolism and Disposition, 41(7), 1450-1456. https://doi.org/10.1124/dmd.113.051805

MeSH terms

LinkOut - more resources