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Review
. 2019 Nov 19:2019:6183965.
doi: 10.1155/2019/6183965. eCollection 2019.

Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds

Rasool Nasiri Kalmarzi #  1 , Seyyed Nima Naleini #  2 , Damoon Ashtary-Larky  3 , Ilaria Peluso  4 , Leila Jouybari  5 , Alireza Rafi  6 , Fereshteh Ghorat  7 , Nishteman Heidari  2 , Faezeh Sharifian  2 , Jalal Mardaneh  8 , Paola Aiello  4   9 , Sobhan Helbi  10 , Wesam Kooti  1
Affiliations
Review

Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds

Rasool Nasiri Kalmarzi et al. Oxid Med Cell Longev. .

Abstract

Berberis vulgaris is a well-known herb in Iran that is widely used as a medicinal plant and a food additive. The aim of this study was to investigate the anti-inflammatory and immunomodulatory effects of Barberry and its main compounds. This narrative review was conducted by searching keywords such as B. vulgaris, Barberry, immunomodulatory, anti-inflammatory, medicinal herbs, plants, and extract, separately or combined in various databases, such as Web of Sciences, PubMed, and Scopus. According to the inclusion and exclusion criteria, just English language articles, which reported effective whole plants or herbal compounds, were included. 21 articles were reviewed in this study. In the in vivo models (mice, rats, and human cells) and in the in vitro models (some organ cells such as the spleen, kidney, blood, and brain), B. vulgaris and its main components showed anti-inflammatory effects in both models. The main mechanisms were the shift of cell immune response to Th2, T reg induction, inhibition of inflammatory cytokines (IL-1, TNF, and IFN-γ), and stimulation of IL-4 and IL-10. The induction of apoptosis in APCs and other effector cells was another important mechanism.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Structure of some important compounds of B. vulgaris.
See this image and copyright information in PMC

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