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Editorial
. 2019 Nov 26;10(63):6755-6757.
doi: 10.18632/oncotarget.27227.

Ezrin, more than a metastatic detERMinant?

Victoria Hoskin  1 , Abdi Ghaffari  1 , Bruce E Elliott  1
Affiliations
Editorial

Ezrin, more than a metastatic detERMinant?

Victoria Hoskin et al. Oncotarget. .
No abstract available

Keywords: breast cancer; ezrin; metastasis; therapeutic target.

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Figures

Figure 1
Figure 1. Role of ezrin in cancer metastasis and drug resistance.
Ezrin is known to promote cancer progression through various molecular mechanisms, as highlighted in the signaling insets. Ezrin facilitates cell migration and invasion through its roles in focal adhesion and invadopodia turnover and cytoskeletal remodeling at the primary tumor site to promote metastasis to lymph nodes; where it contributes to cytotoxic T cell suppression and immune evasion through a PKA-CSK-LCK signaling pathway associated with the T cell receptor; and to more distant organ sites such as the lung were it contributes to cell survival and drug resistance through effects on NF-κB and PI3K/AKT signaling pathways. These multifaceted roles for ezrin in cancer makes it an attractive therapeutic target, where its inhibition may suppress metastasis, promote anti-tumor immunity and enhance cytotoxic drug sensitivity. Illustration was created by Designs That Cell.
See this image and copyright information in PMC

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