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Review
. 2019 Nov 14:2019:6723917.
doi: 10.1155/2019/6723917. eCollection 2019.

Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis

Ling Ling  1 , Feifei Gao  1 , Qinglin Zhang  1 , Tao He  2 , Yi Zhao  2 , Yiqiao Xing  2 , Yifeng Yu  3 , Kaibao Ji  2
Affiliations
Review

Optical Coherence Tomography Angiography Assessed Retinal and Choroidal Microvasculature Features in Patients with Retinitis Pigmentosa: A Meta-Analysis

Ling Ling et al. Biomed Res Int. .

Abstract

Background: The aim of this study was to assess the retinal and choroidal microvasculature features using optical coherence tomography angiography (OCTA) in patients with retinitis pigmentosa (RP).

Methods: This study was a meta-analysis of relevant published studies that were included after a comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases. Mean difference (MD) with a 95% confidence interval was used to assess continuous variable outcomes. Heterogeneity was evaluated using the chi-squared test based on the values of P and I 2.

Results: Seven studies were included in this meta-analysis. The vessel density values measured in the superficial and deep foveal zones of RP patients using OCTA were significantly lower than the recorded values in the control groups (MD = -3.58, P=0.04; MD = -4.93, P=0.02, respectively). The superficial and deep parafoveal vessel density values measured with OCTA were also significantly lower in RP patients than in control groups (MD = -9.09, P < 0.00001; MD = -10.74, P < 0.00001, respectively); for choriocapillaris vessel density, there was no statistically significant difference between RP patients and controls (MD = -1.33, P=0.09). The deep foveal avascular zone (FAZ) was significantly larger in RP patients than in controls (MD = 0.15, P=0.01), whereas there was no significant difference in the superficial foveal avascular zones in the two groups (MD = 0.08, P=0.11).

Conclusions: We showed that retinal and choroidal vessels were attenuated in RP patients. Additionally, we revealed that the FAZ was larger in RP patients, especially the deep FAZ. OCTA may become a useful modality in the diagnosis and monitoring of patients with RP.

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Conflict of interest statement

The authors have no conflicts of interest to this submission.

Figures

Figure 1
Figure 1
Flow diagram of the article search process for meta-analysis.
Figure 2
Figure 2
Forest plot of foveal vessel density in RP groups and control groups.
Figure 3
Figure 3
Forest plot of parafoveal vessel density in RP patients and controls.
Figure 4
Figure 4
Forest plot for choriocapillaris vessel density in RP patients and controls.
Figure 5
Figure 5
Forest plot for analysis of foveal avascular zone superficial and deep in RP patients and controls.
Figure 6
Figure 6
Forest plot for foveal thickness in RP patients and controls.
See this image and copyright information in PMC

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