Polygenic risk scores and the prediction of common diseases

Mika Ala-Korpela^{1

2

3

4

5

6}, Michael V Holmes^{7

8

9}

Affiliations

¹ Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
² Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.
³ NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
⁴ Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
⁵ Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
⁶ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, The Alfred Hospital, Monash University, Melbourne, VIC, Australia.
⁷ Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.
⁸ Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
⁹ National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.

Editorial

Mika Ala-Korpela et al. Int J Epidemiol. 2020.

. 2020 Feb 1;49(1):1-3.

doi: 10.1093/ije/dyz254.

Mika Ala-Korpela^{1

2

3

4

5

6}, Michael V Holmes^{7

8

9}

¹ Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
² Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.
³ NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
⁴ Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
⁵ Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
⁶ Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, The Alfred Hospital, Monash University, Melbourne, VIC, Australia.
⁷ Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.
⁸ Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
⁹ National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK.

No abstract available

References

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1. Chatterjee N, Shi J, García-Closas M.. Developing and evaluating polygenic risk prediction models for stratified disease prevention. Nat Rev Genet 2016;17:392–406. - PMC - PubMed
1. Janssens A, van Duijn CM.. Genome-based prediction of common diseases: advances and prospects. Hum Mol Genet 2008;17:R166–73. - PubMed
1. Wald NJ, Old R.. The illusion of polygenic disease risk prediction. Genet Med 2019;21:1705. - PubMed
1. Abraham G, Havulinna AS, Bhalala OG. et al. Genomic prediction of coronary heart disease. Eur Heart J 2016;37:3267–78. - PMC - PubMed