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. 2020 Feb;121(2):330-336.
doi: 10.1002/jso.25811. Epub 2019 Dec 11.

Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis

Yosuke Kasai  1   2 , Kenzo Hirose  1   2 , Carlos U Corvera  1   2 , Grace E Kim  2   3 , Thomas A Hope  2   4 , Brandon E Shih  2 , Nusrat Harun  2 , Mi-Ok Kim  2   5 , Robert S Warren  1   2 , Emily K Bergsland  2   6 , Eric K Nakakura  1   2
Affiliations

Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis

Yosuke Kasai et al. J Surg Oncol. 2020 Feb.

Abstract

Background and objectives: We developed objective measurements of preoperative and residual tumor volume, and debulking rate, to evaluate their prognostic value for neuroendocrine liver metastasis (NELM).

Methods: Seventy-three patients who underwent surgery for NELM were analyzed retrospectively. Indices of preoperative and postoperative residual tumor volume (pre-volume index [VI] and post-VI) were calculated as the sum of the cubes of individual tumor diameters on preoperative and postoperative imaging, respectively. The debulking rate (%) was calculated as 100 - 100 × post-VI/pre-VI. The classification and regression trees method was used to classify pre-VI and post-VI.

Results: Overall survival (OS) was discriminated by preoperative tumor volume (5-year OS rates, 87.8% for low pre-VI and 60.1% for high pre-VI; P = .037) and residual tumor volume (5-year OS rates, 88.1% for low post-VI and 24.8% for high post-VI; P < .001). In contrast, debulking rates of 100%, ≥90%, and <90% did not discriminate OS (5-year OS rates, 88.0%, 61.9%, and 58.9%, respectively, not significant). In multivariate analysis, residual tumor volume (high post-VI, hazard ratio, 6.40; 95% confidence interval, 1.45-32.3) was an independent prognostic factor for OS.

Conclusions: Objective measurement of tumor volume demonstrates that residual tumor volume is prognostic after surgery for NELM.

Keywords: debulking rate; debulking surgery; grade.

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References

REFERENCES

    1. Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003;97(4):934-959.
    1. Hauso O, Gustafsson BI, Kidd M, et al. Neuroendocrine tumor epidemiology: contrasting Norway and North America. Cancer. 2008;113(10):2655-2664.
    1. Dasari A, Shen C, Halperin D, et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 2017;3(10):1335-1342.
    1. Riihimäki M, Hemminki A, Sundquist K, Sundquist J, Hemminki K. The epidemiology of metastases in neuroendocrine tumors. Int J Cancer. 2016;139(12):2679-2686.
    1. Yao JC, Pavel M, Lombard-Bohas C, et al. Everolimus for the treatment of advanced pancreatic neuroendocrine tumors: overall survival and circulating biomarkers from the randomized, Phase III RADIANT-3 study. J Clin Oncol. 2016;34(32):3906-3913.

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