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. 2019 Dec 11;17(1):214.
doi: 10.1186/s12957-019-1746-x.

Clinical outcomes of complete cytoreduction with concurrent liver resection followed by hyperthermic intraperitoneal chemotherapy for synchronous peritoneal and liver metastatic colorectal cancer

Youngbae Jeon  1 , Eun Jung Park  1 , Jin Hong Lim  2 , Seung Hyuk Baik  3
Affiliations

Clinical outcomes of complete cytoreduction with concurrent liver resection followed by hyperthermic intraperitoneal chemotherapy for synchronous peritoneal and liver metastatic colorectal cancer

Youngbae Jeon et al. World J Surg Oncol. .

Abstract

Background: This study aimed to evaluate the clinical outcomes of concurrent liver resection with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in colorectal cancer patients with synchronous liver and peritoneal metastases.

Methods: Patients with colorectal liver and peritoneal metastasis who underwent complete cytoreduction and hyperthermic intraperitoneal chemotherapy with concurrent liver surgery between September 2014 and July 2018 were included. Perioperative outcomes, overall survival, and progression-free survival were analyzed retrospectively.

Results: In total, 22 patients were included. The median peritoneal cancer index was 13 (range, 0-26), and the median number of liver metastases was 3 (range, 1-13). The mean total operative time was 11.4 ± 2.6 h. Minor postoperative complications (Clavien-Dindo grade I-II) were reported in 10 patients (45.5%), and major postoperative complications (grade III-V) were reported in five patients (22.7%), including one mortality patient. The median overall survival since diagnosis with metastasis was 27.4 months. The median overall survival since surgical intervention and the progression-free survival were 16.7 months and 7.1 months, respectively.

Conclusions: This short-term follow-up study showed that, in an experienced center, combined resection with hyperthermic intraperitoneal chemotherapy for colorectal liver and peritoneal metastases was feasible and safe with acceptable oncologic outcomes.

Keywords: Colorectal cancer; Cytoreductive surgery; Hyperthermic intraperitoneal chemotherapy; Liver metastases; Liver resection; Peritoneal metastases.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Scatter plot showing the relation between peritoneal cancer index and number of liver metastasis. PCI peritoneal cancer index
Fig. 2
Fig. 2
Schematic flow diagram showing treatment. CRS cytoreductive surgery, HIPEC hyperthermic intraperitoneal chemotherapy
Fig. 3
Fig. 3
Overall survival and progression-free survival curves (Kaplan-Meier method). a Survival rate since surgery. b Overall survival since diagnosis of metastatic colorectal cancer. OS overall survival, PFS progression-free survival
Fig. 4
Fig. 4
Sites of recurrence after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with concurrent liver surgery
See this image and copyright information in PMC

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