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Review
. 2020 Nov;26(8):1610-1618.
doi: 10.1111/odi.13253. Epub 2020 Jan 22.

Epigenetic alterations in salivary gland tumors

Erison S Dos Santos  1 , Joab C Ramos  1 , Ana Gabriela C Normando  1 , Fernanda V Mariano  2 , Adriana F Paes Leme  3
Affiliations
Review

Epigenetic alterations in salivary gland tumors

Erison S Dos Santos et al. Oral Dis. 2020 Nov.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Oral Dis. 2023 Mar;29(2):853. doi: 10.1111/odi.13819. Epub 2021 Mar 26. Oral Dis. 2023. PMID: 35535028 No abstract available.

Abstract

Salivary gland tumors (SGTs) comprise a heterogeneous group of benign and malignant neoplasms that exhibit significant variability in their microscopic appearance, clinical presentation, and biological behavior. The etiologic factors are unknown; however, chromosomic translocation, secondary radiation, and chemotherapy can be associated with the development of SGT. It has been indicated that epigenetic alterations can be responsible for the development and progress of these neoplasms. The epigenetic mechanisms are defined as a set of DNA changes that do not alter the sequence of nucleotide bases but alter the expression of the proteins. These alterations have been studied in the SGT, and they were associated with the development and progress of these neoplasms and may influence on SGT prognosis. Hence, we critically review the currently available data on the participation of epigenetic events on salivary gland tumors.

Keywords: DNA methylation; epigenetic; histones; non-coding RNA; salivary gland neoplasms.

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References

REFERENCES

    1. Aniello, F., Colella, G., Muscariello, G., Lanza, A., Ferrara, D., Branno, M., & Minucci, S. (2006). Expression of four histone lysine-methyltransferases in parotid gland tumors. Anticancer Research, 26(3A), 2063-2067.
    1. Augello, C., Gregorio, V., Bazan, V., Cammareri, P., Agnese, V., Cascio, S., … Russo, A. (2006). TP53 and p16INK4a, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas. Journal of Cellular Physiology, 207(3), 654-659. https://doi.org/10.1002/jcp.20601
    1. Barau, J., Teissandier, A., Zamudio, N., Roy, S., Nalesso, V., Hérault, Y., … Bourc'his, D. (2016). The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science, 354(6314), 909-912.
    1. Binmadi, N. O., Basile, J. R., Perez, P., Gallo, A., Tandon, M., Elias, W., … Alevizos, I. (2018). mi RNA expression profile of mucoepidermoid carcinoma. Oral Diseases, 24(4), 537-543. https://doi.org/10.1111/odi.12800
    1. Brown, A. L., Al-Samadi, A., Sperandio, M., Soares, A. B., Teixeira, L. N., Martinez, E. F., … Passador-Santos, F. (2019). MiR-455-3p, miR-150 and miR-375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma. Journal of Oral Pathology & Medicine, 48(9), 840-845. https://doi.org/10.1111/jop.12894

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