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. 1988 Oct;26(10):2203-5.
doi: 10.1128/jcm.26.10.2203-2205.1988.

Characterization of a circular plasmid from Borrelia burgdorferi, etiologic agent of Lyme disease

F W Hyde  1 , R C Johnson
Affiliations

Characterization of a circular plasmid from Borrelia burgdorferi, etiologic agent of Lyme disease

F W Hyde et al. J Clin Microbiol. 1988 Oct.

Abstract

Borrelia burgdorferi, the etiologic agent of Lyme disease, was recently shown to contain plasmid DNA. Two plasmid species have been described in strain CT1, a Wisconsin tick isolate: a 9.2-kilobase entity; and a larger, 70-kilobase entity. Characterization of the 9.2-kilobase entity by using DNase I and restriction endonucleases demonstrated that the plasmid is supercoiled and exists as a stable dimer in this strain. The role played by the plasmid in B. burgdorferi is unknown.

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