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Review
. 2019 Dec 12;15(12):e1008097.
doi: 10.1371/journal.ppat.1008097. eCollection 2019 Dec.

Human immunity to Toxoplasma gondii

Daniel Fisch  1 , Barbara Clough  1 , Eva-Maria Frickel  1
Affiliations
Review

Human immunity to Toxoplasma gondii

Daniel Fisch et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Systemic and cellular human response to Toxoplasma infection.
Left: Systemic response to Tg-infection: Infected cells and cells that have phagocytosed Tg parasites at a site of infection sense the presence of the pathogen via the indicated PRRs and defence proteins and react by production of proinflammatory cytokines and chemokines like CCL2, IL-1β, and IL-12. This cytokine presence will trigger IFNγ–production by Th1 and NK cells. Right: Cellular response to Tg-infection: IFNγ and potentially other cytokines trigger infected cells to mount a cell-intrinsic defence against the PV. Mechanisms include ubiquitin-driven non-canonical autophagy of the entire PV and growth stunting; marking the PV with Ub, LAMP1, and the autophagy adapter proteins NDP52 and p62, followed by acidification of the vacuoles and killing of the parasite; recruitment of GBP1 to Tg vacuoles to disrupt them and expose the parasite within or growth restriction of Tg by GBP1 without translocation to the vacuole; and host cell death in response to opened PVs and leakage of pathogen-associated molecular patterns into the cytosol for detection by PRRs. The exact mechanisms highly depend on the cell type and the Tg strain infecting the cells. AIM, absent in melanoma 2; ASC, apoptosis-associated speck-like protein containing a CARD; CASP, caspase; CCL, chemokine (C-C motif) ligand; GBP, guanylate binding protein; IL, interleukin; IFNγ, interferon gamma; LAMP, lysosome-associated membrane protein; NDP52, nuclear domain 10 protein 52; NK, natural killer; NLRP, nucleotide-binding oligomerization domain, Leucine rich repeat and Pyrin domain containing; PAMP, pathogen-associated molecular patterns; PRR, pattern recognition receptor; PV, parasitophorous vacuole; Tg, Toxoplasma gondii; Th, T helper cell; TNFα, tumour necrosis factor α; Ub, Ubiquitin.
See this image and copyright information in PMC

References

    1. Pappas G, Roussos N, Falagas ME. Toxoplasmosis snapshots: Global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J Parasitol. 2009. October 1;39[12]:1385–94. 10.1016/j.ijpara.2009.04.003 - DOI - PubMed
    1. Xiao J, Yolken RH. Strain hypothesis of Toxoplasma gondii infection on the outcome of human diseases. Acta Physiol. 2015. April;213[4]:828–45. - PMC - PubMed
    1. Hill D, Dubey JP. Toxoplasma gondii: transmission, diagnosis and prevention. Clin Microbiol Infect. 2002. October 1;8[10]:634–40. 10.1046/j.1469-0691.2002.00485.x - DOI - PubMed
    1. Harker KS, Ueno N, Lodoen MB. Toxoplasma gondii dissemination: a parasite’s journey through the infected host. Parasite Immunol. 2015. March 1;37[3]:141–9. 10.1111/pim.12163 - DOI - PubMed
    1. Gazzinelli RT, Mendonça-Neto R, Lilue J, Howard J, Sher A. Innate resistance against Toxoplasma gondii: An evolutionary tale of mice, cats, and men. Cell Host Microbe. 2014. February 12;15[2]:132–8. 10.1016/j.chom.2014.01.004 - DOI - PMC - PubMed

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