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. 2019 Dec 12;12(1):805.
doi: 10.1186/s13104-019-4841-8.

Lycopene improves on basic hematological and immunological parameters in diabetes mellitus

Ejike Daniel Eze  1   2 , Adam Moyosore Afodun  3 , Josephine Kasolo  4 , Keneth Iceland Kasozi  5
Affiliations

Lycopene improves on basic hematological and immunological parameters in diabetes mellitus

Ejike Daniel Eze et al. BMC Res Notes. .

Abstract

Objective: Diabetes is associated with an upset of hematological and immunological parameters in humans, however information on the effects of Lycopene is scarce. The aim of the study was to gain information on basic changes in hematological parameters as markers for safety since anemia as a complication in diabetic chemotherapy has been reported.

Results: Lycopene had anti-anemic effects and improved on the immune status of diabetic rats and these observations were dose independent. There was a decrease in neutrophil, low neutrophil-lymphocyte ratio and platelet counts and stable albumin, globulin levels. Lycopene could exert its protective effects through a balance of basic hematological physiological variables.

Keywords: Anemia; Antioxidants; Blood; Carotenoids; Diabetes.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Changes in hematological indices following Lycopene administration in male Wistar rats. a Packed cell volume (PCV), b Hb concentration, C Red blood cell count (RBCs), d Mean corpuscular volume (MCV), e Mean corpuscular hemoglobin count (MCHC) and f Mean corpuscular hemoglobin concentration (MCHC). Since anemia is defined by a significant decrease in PVC, RBCs, and MCV, these acted as markers for anemia in the experimental animals
Fig. 2
Fig. 2
Changes in immunological parameters following Lycopene administration in male Wistar rats. a White blood cell counts (WBCs), b Lymphocyte count, c Neutrophil counts, d Neutrophillymphocyte ratio, e Platelet count, f Red blood cell fragility test, g Total protein, h blood albumin, I globulin content. The immunological activity was reflected by changes in neutrophils, WBCs, and lymphocytes and in diabetes mellitus, these were relatively suppressed. The lymphocyte ratio demonstrated that DM was characterized with significantly elevated neutrophil counts (d) and this was associated with an elevated platelet count. A low total protein count (g) was due to significantly low globulin levels (I) while RBC fragility was lowest in the healthy rats and highest in the diabetic groups
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