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Editorial
. 2019 Dec 12;11(23):10793-10795.
doi: 10.18632/aging.102622. Epub 2019 Dec 12.

Metformin turns off the metabolic switch of pancreatic cancer

Xavier Deschênes-Simard  1 , Marie-Camille Rowell  1 , Gerardo Ferbeyre  1
Affiliations
Editorial

Metformin turns off the metabolic switch of pancreatic cancer

Xavier Deschênes-Simard et al. Aging (Albany NY). .
No abstract available

Keywords: cellular senescence; metformin; mitochondria; pancreatic cancer; tumor-initiating cells.

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Figures

Figure 1
Figure 1
Mitochondrial metabolism and possible mechanisms of metformin sensitivity in pancreatic tumor-initiating cells. (A) Increased mitochondrial gene expression in pancreatic cancer cells compared to PanIN cells. An analysis by microarray was performed as described in Deschenes-Simard et al. and analysed with the FlexArray 1.6.3 software (GEO accession number: GSE57566). The fold increase of relative mRNA levels is indicated in red inside brackets. (B) Potential mechanisms explaining the specific toxicity of metformin on tumor-initiating cells. The inhibition of the TCA cycle by metformin may; impair ROS-dependent signaling, induce bioenergetic stress and reduce the production of critical metabolites required for tumor-initiating cell survival. In addition, metformin may increase the abundance of Akkermansia muciniphila in the gastrointestinal tract, thus protecting against the translocation of LPS in the systemic circulation.
See this image and copyright information in PMC

References

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