Position Statement on the Use of Bone Turnover Markers for Osteoporosis Treatment

Abstract

Current evidences continue to support the clinical application of bone turnover markers (BTMs) in the management of postmenopausal osteoporosis. The limitations of bone mineral density measured by dual energy X-ray absorptiomet especially emphasize the beneficial roles of BTMs, such as serum C-terminal telopeptide of type I collagen and serum procollagen type I N-propeptide, as monitoring tools to assess the responses to treatment. Therefore, the proper application and assessment of BTM in clinical practice is very important. However, their use in Korea is still insufficient. Therefore, the BTM committee has set up by the Korean Society for Bone and Mineral Research have been constituted and provided a position statement which will suggest on the clinical application of BTM for the management of postmenopausal osteoporosis in Korea.

Keywords: Bone remodeling; Osteoporosis; Republic of Korea.

Fig. 1. The algorithm of bone turnover marker use in osteoporosis treatment. PINP, propeptide of type I collagen; BSALP, bone specific alkaline phosphatase; CTX-1, C-terminal telopeptide of type I collagen; NTX-1, N-terminal telopeptide of collagen type I; DPD, deoxypyridinoline; PYD, pyridinoline; BP, bisphosphonate; SERM, selective estrogen receptor modulator; LSC, least significant changes.