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Case Reports
. 2019 Oct 28;6(10):e00262.
doi: 10.14309/crj.0000000000000262. eCollection 2019 Oct.

Gastric Ulcer as Presentation of HIV-Associated Kaposi Sarcoma and Resolution With HAART Therapy

Rama Nassri  1 , Abdullah Muftah  2 , Mayssan Muftah  3 , Ammar Nassri  4 , Ahmad Alkhasawneh  5
Affiliations
Case Reports

Gastric Ulcer as Presentation of HIV-Associated Kaposi Sarcoma and Resolution With HAART Therapy

Rama Nassri et al. ACG Case Rep J. .

Abstract

Kaposi sarcoma (KS) is a neoplasm of endothelium-derived cells that are associated with human herpesvirus 8 infection. In the setting of HIV, extensive disease typically necessitates highly active antiretroviral therapy in conjunction with chemotherapy. We report a patient who presented with gastrointestinal symptoms and was found to have KS presenting only as cratered gastric ulcers. The patient declined chemotherapy and was treated with highly active antiretroviral therapy alone and had complete resolution of KS on endoscopy and imaging up to 3 years later.

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Figures

Figure 1.
Figure 1.
Kaposi sarcoma of the stomach. (A) Spindle cell proliferation in gastric mucosa with intestinal metaplasia, consistent with Kaposi sarcoma (haemotoxylin and eosin stain, 50×). (B) The tumor cells are immunoreactive for HHV-8, which supports the diagnosis of Kaposi sarcoma (nuclear stain with brown chromogen, 50×).
Figure 2.
Figure 2.
Initial endoscopic view of Kaposi sarcoma showing (A) cratered gastric ulcers and at the follow-up showing (B) complete resolution of lesions on HAART.
See this image and copyright information in PMC

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