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. 2019 Oct 19;6(4):328-332.
doi: 10.1016/j.gendis.2019.10.006. eCollection 2019 Dec.

Oxygen sensing and adaptability won the 2019 Nobel Prize in Physiology or medicine

Qing Zhang  1 , Qin Yan  2 , Haifeng Yang  3 , Wenyi Wei  4
Affiliations

Oxygen sensing and adaptability won the 2019 Nobel Prize in Physiology or medicine

Qing Zhang et al. Genes Dis. .

Abstract

The 2019 Nobel Prize in Physiology or Medicine was awarded to three physician scientists, Drs. William G. Kaelin, Jr., Peter Ratcliffe and Gregg Semenza, for their groundbreaking work revealing how cells sense and adapt to oxygen availability. Here, we summarize the history of their discoveries.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Dr. William G. Kaelin Jr. and the authors (A) Dr. Kaelin and his trainees. From left to right: Dr. William Kaelin, Dr. Samuel McBrayer, Dr. Qing Zhang, Dr. Kimberley Briggs and Dr. Alan Baik (B) Dr. Kaelin and Dr. Haifeng Yang (C) Dr. Kaelin and Dr. Wenyi Wei (D) Dr. Kaelin and his trainees. From left to right: Dr. Wenyi Wei, Dr. Qin Yan, Dr. William Kim, Dr. Archana Bommi-Reddy, Dr. William Kaelin, Dr. Lianjie Li and Dr. Yoji Andrew Minamishima (E) Dr. Kaelin and the authors at Fenway Park, Boston, MA on August 31, 2015 after the memorial service for Dr. Kaelin's beloved wife, Dr. Carolyn Kaelin, who died of brain cancer. From left to right: Dr. Qin Yan, Dr. Haifeng Yang, Dr. William Kaelin, Dr. Wenyi Wei, and Dr. Qing Zhang.
Figure 2
Figure 2
Milestones in the history of oxygen sensing research (Reprint permitted by Science Bulletin).
Figure 3
Figure 3
A schematic representation of HIF-1α regulation under normoxic and hypoxic conditions (Reprint permitted by Science Bulletin).
See this image and copyright information in PMC

References

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