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Editorial
. 2020 Mar;46(3):513-515.
doi: 10.1007/s00134-019-05891-9. Epub 2019 Dec 12.

The artificial kidney induces acute kidney injury: yes

N Benichou  1 , Stéphane Gaudry  2   3   4   5 , D Dreyfuss  1   6   7
Affiliations
Editorial

The artificial kidney induces acute kidney injury: yes

N Benichou et al. Intensive Care Med. 2020 Mar.
No abstract available

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Conflict of interest statement

Nicolas Benichou is the recipient of a grant from the Société Francophone de Néphrologie, Dialyse et Transplantation, outside of the submitted work. Stéphane Gaudry reports grants from French ministry of health, during the conduct of AKIKI trial. Didier Dreyfuss reports grants from French ministry of health, during the conduct of AKIKI trial.

Figures

Fig. 1
Fig. 1
Course of acute kidney injury over time. (1) Preventive action can be taken when acute kidney injury (AKI) is discovered at an early stage, and progression to the need for renal replacement therapy (RRT; dotted blue line) can potentially be avoided (full black line). (2) During recovery from AKI, the kidneys are more susceptible to further injury, which can result in new deterioration of renal function (full black line) rather than recovery (green line). (3) Patients can recover their kidney function after starting RRT (full blue line). This recovery is often incomplete, which can result in progressive chronic kidney disease (CKD) and eventually end-stage kidney disease (ESKD; full lilac line). (4) Patients who have had a second AKI hit rarely recover their kidney function completely (full blue line), and have an increased risk of progressive CKD and evolution to ESKD over time (full lilac line). The concept of artificial kidney-induced kidney injury would imply that RRT might constitute this second hit. GFR glomerular filtration rate Reprinted from The Lancet, vol 389, Vanmassenhove J, Kielstein J, Jörres A, Biesen WV, Management of patients at risk of acute kidney injury, pages 2139–2151, copyright 2017, with permission from Elsevier
See this image and copyright information in PMC

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