Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Guideline
. 2019 Feb;117(1):S24-S36.
doi: 10.5546/aap.2019.S24.

[Allergic Reactions to Betalactams in Pediatrics: Recommendations for diagnosis and treatment]

[Article in Spanish]
Comité Nacional de Alergia
Collaborators, Affiliations
Free article
Guideline

[Allergic Reactions to Betalactams in Pediatrics: Recommendations for diagnosis and treatment]

[Article in Spanish]
Comité Nacional de Alergia. Arch Argent Pediatr. 2019 Feb.
Free article

Abstract
in English, Spanish

The Allergic Reactions to Betalactam Antibiotics are adverse events that cannot be explained by their pharmacological action, but mediated by an immunological mechanism. They are the most frequent cause of drug allergy in the world. Betalactam antibiotics include penicillins, cephalosporins, carbapenems, monobactams, cefems (moxalactam, cefoxitin), and clavulanic acid. They can produce immediate, accelerated or delayed allergic reactions. Its diagnostic methodology is complex and it is carried out by well-defined stages. Its timely diagnosis is very important due to the risk involved and the associated costs that demand the alternative use of other antibiotics that supplant them.

Las reacciones alérgicas a antibióticos betalactámicos son eventos adversos no explicables por su acción farmacológica, sino mediados por un mecanismo inmunológico. Son la causa más frecuente de alergia a los fármacos en el mundo. Incluyen penicilinas, cefalosporinas, carbapenems, monobactámicos, cefems (moxalactam, cefoxitina) y ácido clavulánico. Pueden producir reacciones alérgicas inmediatas, aceleradas o tardías. Su metodología diagnóstica es compleja y se realiza por etapas bien definidas. Es muy importante su diagnóstico oportuno, debido al riesgo que implican y a los costos asociados, que demandan el uso alternativo de otros antibióticos que los reemplacen.

Keywords: ampicillin; anaphylaxis; beta-lactams; drug hypersensitivity; penicillin G.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

References

    1. Cortada Macías JM, López Serrano MC, Blasco Sarramián A, Mayorga C, et al. Introducción, conceptos generales, epidemiología. Fisiopatología: los fármacos como antígenos. En: Peláez Hernández A, Dávila González IJ. Tratado de Alergología. Madrid: Ergón; 2007.Págs.1297-324.
    1. Vervloet D, Durham S. Adverse reactions to drugs. BMJ. 1998; 316(7143):1511-4.
    1. Gell P, Combs R (eds.). Clinical aspects of immunology. Oxford: Blackwell Science; 1964.
    1. González Cervera J. Alergia a medicamentos en Atención Primaria. Aproximación práctica. VI Foro de Pediatría de Atención Primaria de Extremadura. 2009.Págs.27-35. [Consulta: 29 de octubre de 2018]. Disponible en: https://spapex.es/foro-pediatrico/2009/alergia-medicamentos.
    1. Demoly P, Adkinson NF, Brockow K, Castells M, et al. International Consensus on drug allergy. Allergy. 2014; 69(4):420-37.

Publication types

MeSH terms

LinkOut - more resources