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Comment
. 2019 Dec 20;132(24):3003-3005.
doi: 10.1097/CM9.0000000000000556.

Response to crizotinib in a patient with metastatic lung spindle cell carcinoma harboring TPM3-ROS1 fusion

Cun-Liang Cai  1 , Ming-Qiang Zhang, Jun Guo, Li-Wan Wang, Jing-Quan Zhao, Wen-Jia Guo, Xiang-Dong Mu
Affiliations
Comment

Response to crizotinib in a patient with metastatic lung spindle cell carcinoma harboring TPM3-ROS1 fusion

Cun-Liang Cai et al. Chin Med J (Engl). .
No abstract available

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Figures

Figure 1
Figure 1
CT and histopathological findings. (A–C) Chest CT before treatment. (A) An 18 mm × 15 mm irregular mass in the apical segment of the right upper lobe with pleura invasion, as indicated by the arrow. (B) Massive right pleura effusion. (C) Metastasis of the left adrenal gland, as indicated by the arrow. (D and E) Histopathological findings of tissue biopsy. The tumor contains mostly diffuse proliferated spindle-shaped tumor cells with partial necrosis and scattered infiltration of lymphocytes. HE staining, original magnification ×100 and HE original magnification ×200, respectively. (F) Spindle-shaped tumor cells were found in the paraffin section of the pleural effusion cell collections, HE staining, original magnification ×200. (G–I) Chest CT findings at the 4-month follow-up after crizotinib treatment. (G) Lung lesions shrank. (H) The pleura effusion nearly vanished. (I) the metastasis of the left adrenal gland eliminated. CT: Computed tomography; HE: Hematoxylin and eosin.
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