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Review
. 2019 Dec 10;11(12):1988.
doi: 10.3390/cancers11121988.

Multi-omics Signatures and Translational Potential to Improve Thyroid Cancer Patient Outcome

Myriem Boufraqech  1 , Naris Nilubol  1
Affiliations
Review

Multi-omics Signatures and Translational Potential to Improve Thyroid Cancer Patient Outcome

Myriem Boufraqech et al. Cancers (Basel). .

Abstract

Recent advances in high-throughput molecular and multi-omics technologies have improved our understanding of the molecular changes associated with thyroid cancer initiation and progression. The translation into clinical use based on molecular profiling of thyroid tumors has allowed a significant improvement in patient risk stratification and in the identification of targeted therapies, and thereby better personalized disease management and outcome. This review compiles the following: (1) the major molecular alterations of the genome, epigenome, transcriptome, proteome, and metabolome found in all subtypes of thyroid cancer, thus demonstrating the complexity of these tumors and (2) the great translational potential of multi-omics studies to improve patient outcome.

Keywords: genomic; methylation; microRNA; proteomic; thyroid cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Genetic alterations involved in thyroid cancer initiation or progression. Abbreviations: N = normal thyroid, FA = follicular adenoma, FTC = follicular thyroid cancer, PTC = papillary thyroid cancer, PDTC = poorly-differentiated thyroid cancer, and ATC = anaplastic thyroid cancer.
See this image and copyright information in PMC

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