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. 2019 Dec 10;11(12):3015.
doi: 10.3390/nu11123015.

Weight Gain and De Novo Metabolic Disorders after Liver Transplantation

Barbara Lattanzi  1 , Daria D'Ambrosio  1 , Daniele Tavano  1 , Demis Pitoni  1 , Gianluca Mennini  2 , Stefano Ginanni Corradini  1 , Massimo Rossi  2 , Manuela Merli  1
Affiliations

Weight Gain and De Novo Metabolic Disorders after Liver Transplantation

Barbara Lattanzi et al. Nutrients. .

Abstract

The development of nutritional and metabolic abnormalities represents an important burden in patients after liver transplantation (LT). Our study aimed at evaluating the incidence, time of onset, and risk factors for nutritional and metabolic abnormalities in patients after LT. The study was a single-center retrospective study. Consecutive patients undergoing elective LT from 2000 to 2016 were enrolled. The presence of at least two among arterial hypertension (AH), diabetes mellitus (DM), dyslipidemia, and obesity (BMI ≥ 30 Kg/m2) was utilized to define patients with the metabolic disorder (MD). Three hundred and fifteen patients were enrolled; the median age was 56 years (68% males). Non-alcoholic steatohepatitis (NASH) was the origin of liver disease in 10% of patients. During follow-up, 39% of patients developed AH, 18% DM, and 17% dyslipidemia. Metabolic disorders were observed in 32% of patients. The NASH etiology (OR: 6.2; CI 95% 0.5-3; p = 0.003) and a longer follow-up (OR: 1.2; CI 95% 0.004-0.02; p = 0.002) were associated with de novo MD. In conclusion, nutritional and metabolic disorders are a frequent complication after LT, being present in up to one-third of patients. The NASH etiology and a longer distance from LT are associated with de novo MD after LT.

Keywords: body mass index (BMI); liver transplantation (LT); metabolic disorders (MDs), non-alcoholic steatohepatitis (NASH).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the study.
Figure 2
Figure 2
BMI modifications in 315 subjects followed after liver transplantation. All patients (dotted line), patients with previous NASH (continue line), patients with no-NASH (dashed–dotted line). * <0.05 compared to BMI at LT.
Figure 3
Figure 3
Prevalence and time of onset of de novo metabolic disorders after LT.
See this image and copyright information in PMC

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