Interferon-free compared to interferon-based antiviral regimens as first-line therapy for B-cell lymphoproliferative disorders associated with hepatitis C virus infection

Marco Frigeni^#^{1

2}, Caroline Besson^#³, Carlo Visco⁴, Helene Fontaine⁵, Maria Goldaniga⁶, Marcella Visentini⁷, Alessandro Pulsoni⁸, Harrys A Torres⁹, Jan Peveling-Oberhag^{10

11}, Roberto Rossotti¹², Francesco Zaja¹³, Luigi Rigacci¹⁴, Michele Merli¹⁵, Céline Dorival¹⁶, Camille Alric¹⁷, Francesco Piazza¹⁸, Massimo Gentile¹⁹, Angela Ferrari²⁰, Mario Pirisi²¹, Luca Nassi²², Sara Rattotti², Annamaria Frustaci²³, Michele Milella²⁴, Emanuele Cencini²⁵, Irene Defrancesco¹, Virginia Valeria Ferretti¹, Raffaele Bruno^{26

27}, Olivier Hermine^#^{28

29}, Luca Arcaini^#^{30

31}

Affiliations

¹ Department of Molecular Medicine, University of Pavia, Pavia, Italy.
² Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
³ APHP CHU Bicêtre, Université Paris Sud, INSERM U1012, Orsay, France.
⁴ Department of Medicine, Section of Hematology, University of Verona, Verona, Italy.
⁵ Department of Hepatology, Inserm U-1213 and UMS-20, Institut Pasteur, Paris 5 Descartes University, Paris, France.
⁶ Department of Hematology, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy.
⁷ Department of Translational and Precision Medicine, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.
⁸ Division of Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Fondazione Roma, Rome, Italy.
⁹ Department of Infectious Diseases, Infection Control, and Employee Health, and Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
¹⁰ Department of Internal Medicine 1, Goethe-University Hospital, Frankfurt, Germany.
¹¹ Department of Internal Medicine 1, Robert-Bosch-Krankenhaus, Stuttgart, Germany.
¹² Department of Infectious Diseases, Ospedale Niguarda Ca' Granda, Milano, Italy.
¹³ Hematology Unit, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.
¹⁴ Hematology Unit and Bone Marrow Transplant Unit, San Camillo Forlanini Hospital, Rome, Italy.
¹⁵ Division of Hematology, Ospedale di Circolo e Fondazione Macchi, University of Insubria, Varese, Italy.
¹⁶ Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique, F75012, Paris, France.
¹⁷ Hematology Department, Institut Universitaire du Cancer de Toulouse-Oncopole (IUCT-O) Toulouse 3 University, Paris, France.
¹⁸ Hematology and Clincal Immunology Branch, Department of Medecine, University of Padova, Padova, Italy.
¹⁹ Hematology Unit, Department of Onco-Hematology, A.O. of Cosenza, Cosenza, Italy.
²⁰ Division of Hematology, Azienda USL IRCCS Reggio Emilia, Reggio Emilia, Italy.
²¹ Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.
²² Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
²³ Department of Hematology, Ospedale Niguarda Ca' Granda, Milano, Italy.
²⁴ Division of Infectious Diseases, University Hospital Policlinico Consorziale, Bari, Italy.
²⁵ Division of Hematology, Azienda Ospedaliera Senese, University of Siena, Siena, Italy.
²⁶ Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
²⁷ Division of Infectious and Tropical Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
²⁸ AP-HP, Department of Adult Hematology and Imagine Institute, Hôpital Necker, University of Paris, Paris, France.
²⁹ INSERM U 1163, CNRS ERL 8254, Imagine Institute, Université Sorbonne Paris Cité, Paris, France.
³⁰ Department of Molecular Medicine, University of Pavia, Pavia, Italy. luca.arcaini@unipv.it.
³¹ Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. luca.arcaini@unipv.it.

^# Contributed equally.

PMID: 31836855
DOI: 10.1038/s41375-019-0687-2

Comparative Study

Interferon-free compared to interferon-based antiviral regimens as first-line therapy for B-cell lymphoproliferative disorders associated with hepatitis C virus infection

Marco Frigeni et al. Leukemia. 2020 May.

. 2020 May;34(5):1462-1466.

doi: 10.1038/s41375-019-0687-2. Epub 2019 Dec 13.

Authors

Affiliations

¹ Department of Molecular Medicine, University of Pavia, Pavia, Italy.
² Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
³ APHP CHU Bicêtre, Université Paris Sud, INSERM U1012, Orsay, France.
⁴ Department of Medicine, Section of Hematology, University of Verona, Verona, Italy.
⁵ Department of Hepatology, Inserm U-1213 and UMS-20, Institut Pasteur, Paris 5 Descartes University, Paris, France.
⁶ Department of Hematology, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy.
⁷ Department of Translational and Precision Medicine, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.
⁸ Division of Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Fondazione Roma, Rome, Italy.
⁹ Department of Infectious Diseases, Infection Control, and Employee Health, and Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
¹⁰ Department of Internal Medicine 1, Goethe-University Hospital, Frankfurt, Germany.
¹¹ Department of Internal Medicine 1, Robert-Bosch-Krankenhaus, Stuttgart, Germany.
¹² Department of Infectious Diseases, Ospedale Niguarda Ca' Granda, Milano, Italy.
¹³ Hematology Unit, Azienda Sanitaria Universitaria Integrata, Trieste, Italy.
¹⁴ Hematology Unit and Bone Marrow Transplant Unit, San Camillo Forlanini Hospital, Rome, Italy.
¹⁵ Division of Hematology, Ospedale di Circolo e Fondazione Macchi, University of Insubria, Varese, Italy.
¹⁶ Sorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique, F75012, Paris, France.
¹⁷ Hematology Department, Institut Universitaire du Cancer de Toulouse-Oncopole (IUCT-O) Toulouse 3 University, Paris, France.
¹⁸ Hematology and Clincal Immunology Branch, Department of Medecine, University of Padova, Padova, Italy.
¹⁹ Hematology Unit, Department of Onco-Hematology, A.O. of Cosenza, Cosenza, Italy.
²⁰ Division of Hematology, Azienda USL IRCCS Reggio Emilia, Reggio Emilia, Italy.
²¹ Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.
²² Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
²³ Department of Hematology, Ospedale Niguarda Ca' Granda, Milano, Italy.
²⁴ Division of Infectious Diseases, University Hospital Policlinico Consorziale, Bari, Italy.
²⁵ Division of Hematology, Azienda Ospedaliera Senese, University of Siena, Siena, Italy.
²⁶ Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
²⁷ Division of Infectious and Tropical Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
²⁸ AP-HP, Department of Adult Hematology and Imagine Institute, Hôpital Necker, University of Paris, Paris, France.
²⁹ INSERM U 1163, CNRS ERL 8254, Imagine Institute, Université Sorbonne Paris Cité, Paris, France.
³⁰ Department of Molecular Medicine, University of Pavia, Pavia, Italy. luca.arcaini@unipv.it.
³¹ Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. luca.arcaini@unipv.it.

^# Contributed equally.

PMID: 31836855
DOI: 10.1038/s41375-019-0687-2

No abstract available

PubMed Disclaimer

References

1. Hermine O, Lefrère F, Bronowicki J-P, Mariette X, Jondeau K, Eclache-Saudreau V, et al. Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C Virus Infection. N Engl J Med. 2002. https://doi.org/10.1056/NEJMoa013376 .
1. Saadoun D, Suarez F, Lefrere F, Valensi F, Mariette X, Aouba A, et al. Splenic lymphoma with villous lymphocytes, associated with type II cryoglobulinemia and HCV infection: a new entity? Blood. 2005. https://doi.org/10.1182/blood-2004-05-1711 .
1. Vallisa D, Bernuzzi P, Arcaini L, Sacchi S, Callea V, Marasca R, et al. Role of anti-hepatitis C virus (HCV) treatment in HCV-related, low-grade, B-cell, non-Hodgkin’s lymphoma: a multicenter Italian experience. J Clin Oncol. 2005. https://doi.org/10.1200/JCO.2005.06.008 .
1. Couronné L, Bachy E, Roulland S, Nadel B, Davi F, Armand M, et al. From hepatitis C virus infection to B-cell lymphoma. Ann. Oncol. 2018. https://doi.org/10.1093/annonc/mdx635 .
1. Webster DP, Klenerman P, Dusheiko GM. Lancet seminar—hepatitis C. Lancet. 2015. https://doi.org/10.1016/S0140-6736(14)62401-6 .

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Interferon-free compared to interferon-based antiviral regimens as first-line therapy for B-cell lymphoproliferative disorders associated with hepatitis C virus infection

Affiliations

Interferon-free compared to interferon-based antiviral regimens as first-line therapy for B-cell lymphoproliferative disorders associated with hepatitis C virus infection

Authors

Affiliations

References

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LinkOut - more resources

Full Text Sources

Medical