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Comment
. 2020 Mar;16(3):135-136.
doi: 10.1038/s41581-019-0242-4.

CUBN variants uncouple proteinuria from kidney function

Catherine Quinlan  1   2   3
Affiliations
Comment

CUBN variants uncouple proteinuria from kidney function

Catherine Quinlan. Nat Rev Nephrol. 2020 Mar.
No abstract available

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Comment on

  • Human C-terminal CUBN variants associate with chronic proteinuria and normal renal function.
    Bedin M, Boyer O, Servais A, Li Y, Villoing-Gaudé L, Tête MJ, Cambier A, Hogan J, Baudouin V, Krid S, Bensman A, Lammens F, Louillet F, Ranchin B, Vigneau C, Bouteau I, Isnard-Bagnis C, Mache CJ, Schäfer T, Pape L, Gödel M, Huber TB, Benz M, Klaus G, Hansen M, Latta K, Gribouval O, Morinière V, Tournant C, Grohmann M, Kuhn E, Wagner T, Bole-Feysot C, Jabot-Hanin F, Nitschké P, Ahluwalia TS, Köttgen A, Andersen CBF, Bergmann C, Antignac C, Simons M. Bedin M, et al. J Clin Invest. 2020 Jan 2;130(1):335-344. doi: 10.1172/JCI129937. J Clin Invest. 2020. PMID: 31613795 Free PMC article. Clinical Trial.

References

    1. Roscioni, S. S., Heerspink, H. J. L. & de Zeeuw, D. Microalbuminuria: target for renoprotective therapy PRO. Kidney Int. 86, 40–49 (2014). - DOI
    1. Bedin, M. et al. Human C-terminal CUBN variants associate with chronic proteinuria and normal renal function. J. Clin. Invest. https://doi.org/10.1172/JCI129937 (2019). - DOI
    1. Jayasinghe, K. et al. Isolated proteinuria due to CUBN homozygous mutation – challenging the investigative paradigm. BMC Nephrol. 20, 330 (2019). - DOI
    1. Kashtan, C. E. et al. Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative. Pediatr. Nephrol. 28, 5–11 (2013). - DOI
    1. Brenner, B. M. et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N. Engl. J. Med. 345, 861–869 (2001). - DOI

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