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Comment
. 2020 Feb;17(2):71-72.
doi: 10.1038/s41571-019-0315-0.

Improved MHC II epitope prediction - a step towards personalized medicine

Tamson V Moore  1 , Michael I Nishimura  2
Affiliations
Comment

Improved MHC II epitope prediction - a step towards personalized medicine

Tamson V Moore et al. Nat Rev Clin Oncol. 2020 Feb.

Abstract

Numerous neoepitope-based vaccination strategies are in testing for clinical use in the treatment of cancer. Rapid identification of immunostimulatory neoantigen targets hastens neoantigen vaccine development. Papers recently published in Nature Biotechnology describe two independent machine-learning-based algorithms that demonstrate improved identification of MHC class II-binding peptides. Herein, we outline the benefits of these algorithms and their implications for future immunotherapies.

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Conflict of interest statement

The authors declare no competing interests.

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References

    1. Keenan TE, Burke KP, Van Allen EM. Genomic correlates of response to immune checkpoint blockade. Nat. Med. 2019;25:389–402. doi: 10.1038/s41591-019-0382-x. - DOI - PMC - PubMed
    1. Ott PA, et al. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017;547:217–221. doi: 10.1038/nature22991. - DOI - PMC - PubMed
    1. Alspach E, et al. MHC-II neoantigens shape tumour immunity and response to immunotherapy. Nature. 2019;574:696–701. doi: 10.1038/s41586-019-1671-8. - DOI - PMC - PubMed
    1. Bassani-Sternberg M, et al. Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry. Nat. Commun. 2016;7:13404. doi: 10.1038/ncomms13404. - DOI - PMC - PubMed
    1. Racle J, et al. Robust prediction of HL A class II epitopes by deep motif deconvolution of immunopeptidomes. Nat. Biotechnol. 2019;37:1283–1286. doi: 10.1038/s41587-019-0289-6. - DOI - PubMed